2112809-98-8
2112809-98-8
Chemical Structure
JC-171
- CAS No.: 2112809-98-8
- Formula:C16H17ClN2O5S
- Molecular Weight:384.83
IUPAC Name: 5-chloro-N-(4-(N-hydroxysulfamoyl)phenethyl)-2-methoxybenzamide
InChIKey: KQRQPMUPYDOTCA-UHFFFAOYSA-N
SMILES: O=C(NCCC1=CC=C(S(=O)(NO)=O)C=C1)C2=CC(Cl)=CC=C2OC
Biological Activity: JC-171 is a selective NLRP3 inflammasome inhibitor, with an IC50 of 8.45 μM for inhibiting LPS/ATP-induced interleukin-1β (IL-1β) release from J774A.1 macrophages[1].
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JC-171 | 98.06% | JC-171 is a selective NLRP3 inflammasome inhibitor, with an IC50 of 8.45 μM for inhibiting LPS/ATP-induced interleukin-1β (IL-1β) release from J774A.1 macrophages. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.90
HY-120007JC124 -
Similarity Score 0.88
HY-W011082RNLRP3-IN-2 (Standard) -
Similarity Score 0.76
HY-15210Meglitinide -
Similarity Score 0.72
HY-15206RGlibenclamide (Standard) -
Similarity Score 0.71
HY-1171604-trans-Hydroxy-glibenclamide -
Similarity Score 0.70
HY-1268453-cis-Hydroxyglibenclamide -
Similarity Score 0.65
HY-15208AClamikalant -
Similarity Score 0.64
HY-15206S1Glyburide-d3 -
Similarity Score 0.64
HY-15206AGlibenclamide potassium -
Explore the MedChemAI to find more analogs
References
- [1]. Chunqing Guo, et al. Development and Characterization of a Hydroxyl-Sulfonamide Analogue, 5-Chloro-N-[2-(4-hydroxysulfamoyl-phenyl)-ethyl]-2-methoxy-benzamide, as a Novel NLRP3 Inflammasome Inhibitor for Potential Treatment of Multiple Sclerosis. ACS Chem Neurosci. 2017 Oct 18;8(10):2194-2201. [Content Brief]
