2147-59-3
Chemical Structure
Thymidine-5'-diphosphate-L-rhamnose
Synonym(s): dTDP-L-Rhamnose
- CAS No.: 2147-59-3
- Formula:C16H26N2O15P2
- Molecular Weight:548.33
IUPAC Name: (7S,13aS)-1-hydroxy-2,3,9,10-tetramethoxy-7-methyl-5,6,7,8,13,13a-hexahydroisoquinolino[3,2-a]isoquinolin-7-ium perchlorate
InChIKey: ZOSQFDVXNQFKBY-CGAXJHMRSA-N
SMILES: O[C@H]1C[C@H](N2C=C(C)C(NC2=O)=O)O[C@@H]1COP(O)(OP(O)(O[C@@H]3[C@@H]([C@@H]([C@H]([C@@H](O3)C)O)O)O)=O)=O
Biological Activity: Thymidine-5'-diphosphate-L-rhamnose (dTDP-L-Rhamnose) is a key activated nucleotide sugar in bacteria, with a KD value of 13 μM for Listeria monocytogenes RmlT. Thymidine-5'-diphosphate-L-rhamnose acts as a high-energy donor for L-Rhamnose (HY-N1420), and is specifically used for the synthesis of bacterial cell wall polysaccharides, capsules and virulence factors[1][2].
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Thymidine-5'-diphosphate-L-rhamnose | Thymidine-5'-diphosphate-L-rhamnose (dTDP-L-Rhamnose) is a key activated nucleotide sugar in bacteria, with a KD value of 13 μM for Listeria monocytogenes RmlT. Thymidine-5'-diphosphate-L-rhamnose acts as a high-energy donor for L-Rhamnose (HY-N1420), and is specifically used for the synthesis of bacterial cell wall polysaccharides, capsules and virulence factors. | |||||||||||||||||||||
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References
- [1]. Monteiro R, et al. Molecular properties of the RmlT wall teichoic acid rhamnosyltransferase that modulates virulence in Listeria monocytogenes. Nat Commun. 2025;16(1):24. Published 2025 Jan 2. [Content Brief]
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[2]. Coelho JF. Biosynthesis, Isolation and Magnetization of gellan spheres for biorecognition of therapeutic His-tag proteins (Master's thesis, Universidade da Beira Interior (Portugal)).
