2201066-53-5
2201066-53-5
Chemical Structure
AGI-24512
- CAS No.: 2201066-53-5
- Formula:C24H24N4O2
- Molecular Weight:400.47
IUPAC Name: 6-(4-hydroxyphenyl)-5-methyl-2-phenyl-3-(piperidin-1-yl)pyrazolo[1,5-a]pyrimidin-7(4H)-one
InChIKey: JDHPOXNOROPDTE-UHFFFAOYSA-N
SMILES: O=C1C(C2=CC=C(O)C=C2)=C(C)NC3=C(N4CCCCC4)C(C5=CC=CC=C5)=NN13
Biological Activity: AGI-24512 is a potent methionine adenosyltransferase 2α (MAT2A) inhibitor, with an IC50 of 8 nM. AGI-24512 triggers DNA damage response. AGI-24512 can block proliferation of MTAP-deleted cancer cells in vitro. AGI-24512 can be used for researching anticancer[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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AGI-24512 | 99.46% | AGI-24512 is a potent methionine adenosyltransferase 2α (MAT2A) inhibitor, with an IC50 of 8 nM. AGI-24512 triggers DNA damage response. AGI-24512 can block proliferation of MTAP-deleted cancer cells in vitro. AGI-24512 can be used for researching anticancer. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.57
HY-182400AGI-25696 -
Similarity Score 0.53
HY-138630AG-270 -
Similarity Score 0.52
HY-103456PHTPP -
Similarity Score 0.51
HY-161702RO6806051 -
Similarity Score 0.51
HY-112129AGI25696-analog -
Similarity Score 0.50
HY-122914KRAS inhibitor-3 -
Similarity Score 0.50
HY-116800FR194921 -
Similarity Score 0.48
HY-184700HIV-1-IN-94 -
Similarity Score 0.48
HY-112131MAT2A inhibitor 1 -
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