2221707-61-3
2221707-61-3
Chemical Structure
PTP1B-IN-24
- CAS No.: 2221707-61-3
- Formula:C22H16N2O5S
- Molecular Weight:420.44
InChIKey: UGMVFZBUJLCYOC-ZDLGFXPLSA-N
SMILES: O=C(S/1)N(CC(NC2=CC=C(C)C=C2)=O)C(C1=C\C3=COC4=CC=CC=C4C3=O)=O
Biological Activity: PTP1B-IN-24 (Compound 9) is a reversible PTP1B inhibitor with an IC50 value of 1.4 μM, and PTP1B-IN-24 can enhance the thermal stability of PTP1B. PTP1B-IN-24 can restore PA- (HY-N0830) induced insulin resistance by increasing the phosphorylation levels of IRS1 and AKT[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
PTP1B-IN-24 | 98.46% | PTP1B-IN-24 (Compound 9) is a reversible PTP1B inhibitor with an IC50 value of 1.4 μM, and PTP1B-IN-24 can enhance the thermal stability of PTP1B. PTP1B-IN-24 can restore PA- (HY-N0830) induced insulin resistance by increasing the phosphorylation levels of IRS1 and AKT. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
Structural Analogs
-
Similarity Score 0.58
HY-117131ZINC17167211 -
Similarity Score 0.58
HY-147902VEGFR-2-IN-24 -
Similarity Score 0.57
HY-146988hCAIX/XII-IN-1 -
Similarity Score 0.56
HY-146980GLUT4-IN-2 -
Similarity Score 0.55
HY-147934HDAC8-IN-3 -
Similarity Score 0.54
HY-168719PPARγ agonist 16 -
Similarity Score 0.53
HY-156276SP4e -
Similarity Score 0.52
HY-156277SP4f -
Similarity Score 0.52
HY-163646(Rac)-TZ3O -
Explore the MedChemAI to find more analogs
