223499-30-7
223499-30-7
Chemical Structure
YM-58483
Synonym(s): BTP2
- CAS No.: 223499-30-7
- Formula:C15H9F6N5OS
- Molecular Weight:421.32
IUPAC Name: N-(4-(3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)-4-methyl-1,2,3-thiadiazole-5-carboxamide
InChIKey: XPRZIORDEVHURQ-UHFFFAOYSA-N
SMILES: O=C(C1=C(C)N=NS1)NC2=CC=C(N3N=C(C(F)(F)F)C=C3C(F)(F)F)C=C2
Biological Activity: YM-58483 (BTP2) is the first selective and potent inhibitor of CRAC channels and subsequent Ca2+ signals. YM-584832 is a blocker of store-operated Ca2+ entry (SOCE)[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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YM-58483 | 99.38% | YM-58483 (BTP2) is the first selective and potent inhibitor of CRAC channels and subsequent Ca2+ signals. YM-584832 is a blocker of store-operated Ca2+ entry (SOCE). | ||||||||||||||||||||
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YM-58483 (Standard) | ≥98% | YM-58483 (Standard) is the analytical standard of YM-58483. This product is intended for research and analytical applications. YM-58483 (BTP2) is the first selective and potent inhibitor of CRAC channels and subsequent Ca2+ signals. YM-584832 is a blocker of store-operated Ca2+ entry (SOCE). | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.73
HY-150051IL-2-IN-1 -
Similarity Score 0.71
HY-12504Pyr6 -
Similarity Score 0.64
HY-19408Pyr10 -
Similarity Score 0.63
HY-20588CRAC intermediate 2 -
Similarity Score 0.57
HY-112778NFAT Transcription Factor Regulator-1 -
Similarity Score 0.50
HY-17517Tiadinil -
Similarity Score 0.50
HY-112799DK419 -
Similarity Score 0.50
HY-Z8677Cetirizine impurity 12 -
Similarity Score 0.49
HY-W013164RSC-58125 (Standard) -
Explore the MedChemAI to find more analogs
References
- [1]. Qi Z, et al. The Central Analgesic Mechanism of YM-58483 in Attenuating Neuropathic Pain in Rats. Cell Mol Neurobiol. 2016 Oct;36(7):1035-43 [Content Brief]
- [2]. Ohga K, et al. Characterization of YM-58483/BTP2, a novel store-operated Ca2+ entry blocker, on T cell-mediated immune responses in vivo. Int Immunopharmacol. 2008 Dec 20;8(13-14):1787-9 [Content Brief]
