2. Immunology/Inflammation
  3. Interleukin Related
  4. IL-2-IN-1

IL-2-IN-1 is a potent IL-2 inhibitor with an IC50 value of 1978 nM. IL-2-IN-1 shows antiproliferative activities.

For research use only. We do not sell to patients.

IL-2-IN-1 Chemical Structure

IL-2-IN-1 Chemical Structure

CAS No. : 245747-10-8

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5 mg USD 195 In-stock
10 mg USD 310 In-stock
25 mg USD 620 In-stock
50 mg USD 990 In-stock
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Based on 1 publication(s) in Google Scholar

IL-2-IN-1 Related Antibodies

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  • Biological Activity

  • Purity & Documentation

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Description

IL-2-IN-1 is a potent IL-2 inhibitor with an IC50 value of 1978 nM. IL-2-IN-1 shows antiproliferative activities[1].

IC50 & Target[1]

IL-2

1978 nM (IC50)

In Vitro

IL-2-IN-1 (compound 2) shows antiproliferative activities with IC50s of 340, 1266 nM for human PBMC and rat PBMC, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

IL-2-IN-1 Related Antibodies
Molecular Weight

418.29

Formula

C17H12F6N4O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

FC(F)(C1=CC(C(F)(F)F)=NN1C2=CC=C(NC(C3=C(ON=C3C)C)=O)C=C2)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (298.84 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3907 mL 11.9534 mL 23.9069 mL
5 mM 0.4781 mL 2.3907 mL 4.7814 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3907 mL 11.9534 mL 23.9069 mL 59.7671 mL
5 mM 0.4781 mL 2.3907 mL 4.7814 mL 11.9534 mL
10 mM 0.2391 mL 1.1953 mL 2.3907 mL 5.9767 mL
15 mM 0.1594 mL 0.7969 mL 1.5938 mL 3.9845 mL
20 mM 0.1195 mL 0.5977 mL 1.1953 mL 2.9884 mL
25 mM 0.0956 mL 0.4781 mL 0.9563 mL 2.3907 mL
30 mM 0.0797 mL 0.3984 mL 0.7969 mL 1.9922 mL
40 mM 0.0598 mL 0.2988 mL 0.5977 mL 1.4942 mL
50 mM 0.0478 mL 0.2391 mL 0.4781 mL 1.1953 mL
60 mM 0.0398 mL 0.1992 mL 0.3984 mL 0.9961 mL
80 mM 0.0299 mL 0.1494 mL 0.2988 mL 0.7471 mL
100 mM 0.0239 mL 0.1195 mL 0.2391 mL 0.5977 mL
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IL-2-IN-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IL-2-IN-1245747-10-8Interleukin RelatedILantiproliferativePBMCbis(trifluoromethyl)pyrazoles (BTPs)Inhibitorinhibitorinhibit

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