2238839-34-2
2238839-34-2
Chemical Structure
FKK6
- CAS No.: 2238839-34-2
- Formula:C23H18N2O3S
- Molecular Weight:402.47
InChIKey: VOFKHNAVOAQCBE-UHFFFAOYSA-N
SMILES: C#CCC(O)(C1=CC=NC=C1)C2=CC3=CC=CC=C3N2S(=O)(C4=CC=CC=C4)=O
Biological Activity: FKK6 is a selective agonist for pregnane X receptor (PXR) with an EC50 of 1.2 µM. FKK6 exhibits good affinity with plasma proteins, and good metabolic metabolism in human microsomes. FKK6 inhibits PXR-related NF-κB signaling pathway, inhibits the expression of inflammatory factors, and exhibits anti-inflammatory activity against DSS (HY-116282)-induced colitis in mouse model[1][2].
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FKK6 | 99.14% | FKK6 is a selective agonist for pregnane X receptor (PXR) with an EC50 of 1.2 µM. FKK6 exhibits good affinity with plasma proteins, and good metabolic metabolism in human microsomes. FKK6 inhibits PXR-related NF-κB signaling pathway, inhibits the expression of inflammatory factors, and exhibits anti-inflammatory activity against DSS (HY-116282)-induced colitis in mouse model. | ||||||||||||||||||||
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References
- [1]. Dvořák Z, et al., In vitro safety signals for potential clinical development of the anti-inflammatory pregnane X receptor agonist FKK6. Bioorg Chem. 2024 Mar;144:107137. [Content Brief]
- [2]. Dvořák Z, et al., Targeting the pregnane X receptor using microbial metabolite mimicry. EMBO Mol Med. 2020 Apr 7;12(4):e11621. [Content Brief]
