2254299-48-2
2254299-48-2
Chemical Structure
Linustedastatum
Synonym(s): Linustedastat; FOR-6219; OG-6219
- CAS No.: 2254299-48-2
- Formula:C26H29F2N3O2
- Molecular Weight:453.52
InChIKey: RMMVCLGAUPAFAI-MLXDORPZSA-N
SMILES: C[C@@]12[C@]([C@@H](C/C2=N\O)CCC(NC3=CC=C(C=N3)F)=O)([H])[C@@]4([H])[C@@](CC1)([H])C5=CC=CC(F)=C5CC4
Biological Activity: Linustedastatum (Linustedastat) is a selective HSD17β1 inhibitor. Linustedastat is designed to reduce local estrogen activity by selectively blocking the conversion of intralesional Estrone (HY-B0234) to Estrogen. Linustedastatum can be used in research on endometriosis-related pain[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Linustedastatum | 98.10% | Linustedastatum (Linustedastat) is a selective HSD17β1 inhibitor. Linustedastat is designed to reduce local estrogen activity by selectively blocking the conversion of intralesional Estrone (HY-B0234) to Estrogen. Linustedastatum can be used in research on endometriosis-related pain. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.47
HY-111845Estrone-N-O-C1-amido -
Similarity Score 0.47
HY-43962CS-1-65 -
Similarity Score 0.44
HY-143585CDK9-IN-14 -
Similarity Score 0.43
HY-W0093004-Hydroxyestrone -
Similarity Score 0.43
HY-1287904-Methoxyestrone -
Similarity Score 0.43
HY-159577Nic-15 -
Similarity Score 0.42
HY-148173NUCC-0223619 -
Similarity Score 0.42
HY-173067IDO1 ligand-1 -
Similarity Score 0.42
HY-11334416α-Hydroxyestrone -
Explore the MedChemAI to find more analogs
References
- [1]. Resch V, et al. Targeting Steroid-Metabolizing Enzymes with 15β-Substituted Estrone Analogues: Dual Discovery of AKR1C2/17β-HSD1 Inhibitors and a Fluorescent 17β-HSD1 Ligand. Cancers. 2026 Jun 10;18(12):1889.
- [2]. Arbelaez F, et al. A Phase 2a/b, Randomized, Double-Blind, Placebo-Controlled, Parallel Group, Study to Evaluate the Efficacy and Safety of Linustedastat (OG-6219) in Women with Moderate to Severe Endometriosis-Related Pain. International Journal of Women's Health. 2026 Dec 31:622776.
