2255-14-3
Chemical Structure
Galactose 1-phosphate
- CAS No.: 2255-14-3
- Formula:C6H13O9P
- Molecular Weight:260.14
IUPAC Name: (2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl dihydrogen phosphate
InChIKey: HXXFSFRBOHSIMQ-FPRJBGLDSA-N
SMILES: O=P(O)(O)O[C@H]1O[C@@H]([C@H](O)[C@H](O)[C@H]1O)CO
Biological Activity: Galactose 1-phosphate acts as a competitive substrate inhibitor of galactose-1-phosphate uridylyltransferase (GALT). Galactose 1-phosphate is a competitive inhibitor of Phosphoglucomutase, yet the rate at which this enzyme converts Galactose 1-phosphate to Galactose-6-phosphate is 400 times slower than the rate of converting Glucose-1-phosphate. Galactose 1-phosphate can be used in studies related to Saccharomyces cerevisiae infection and type I galactosemia[1][2].
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Galactose 1-phosphate | Galactose 1-phosphate acts as a competitive substrate inhibitor of galactose-1-phosphate uridylyltransferase (GALT). Galactose 1-phosphate is a competitive inhibitor of Phosphoglucomutase, yet the rate at which this enzyme converts Galactose 1-phosphate to Galactose-6-phosphate is 400 times slower than the rate of converting Glucose-1-phosphate. Galactose 1-phosphate can be used in studies related to Saccharomyces cerevisiae infection and type I galactosemia. | |||||||||||||||||||||
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- [1]. McCorvie TJ, et al. The structural and molecular biology of type I galactosemia: Enzymology of galactose 1-phosphate uridylyltransferase. IUBMB Life. 2011;63(9):694-700. [Content Brief]
- [2]. de Jongh WA, et al. The roles of galactitol, galactose-1-phosphate, and phosphoglucomutase in galactose-induced toxicity in Saccharomyces cerevisiae. Biotechnol Bioeng. 2008;101(2):317-326. [Content Brief]
Keywords
