22611-34-3
22611-34-3
Chemical Structure
Chaparrinone
- CAS No.: 22611-34-3
- Formula:C20H26O7
- Molecular Weight:378.42
InChIKey: VLYMLZRDCSQUQF-RZUZYEBMSA-N
SMILES: C[C@@]12[C@]3([H])[C@@]45[C@@](OC(C[C@@]4([H])[C@H]([C@H]([C@@]3(OC5)O)O)C)=O)([H])C[C@@]1([H])C(C)=CC([C@H]2O)=O
Biological Activity: Chaparrinone is a quassinoid that can be isolated from the root of Eurycoma harmandiana. Chaparrinone has antimalarial and cytotoxic activities against Plasmodium falciparum and P-388 cells (IC50: 0.037 and 0.34 μg/mL respectively)[1][2].
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Chaparrinone | Chaparrinone is a quassinoid that can be isolated from the root of Eurycoma harmandiana. Chaparrinone has antimalarial and cytotoxic activities against Plasmodium falciparum and P-388 cells (IC50: 0.037 and 0.34 μg/mL respectively). | |||||||||||||||||||||
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References
- [1]. Kanchanapoom T, et al. Quassinoids from Eurycoma harmandiana. Phytochemistry. 2001 Aug;57(8):1205-8. [Content Brief]
- [2]. François G, et al. Antimalarial and cytotoxic potential of four quassinoids from Hannoa chlorantha and Hannoa klaineana, and their structure-activity relationships. Int J Parasitol. 1998 Apr;28(4):635-40. [Content Brief]
