2275619-98-0
2275619-98-0
Chemical Structure
MDL-811
- CAS No.: 2275619-98-0
- Formula:C25H25BrCl2FN3O5S2
- Molecular Weight:681.42
InChIKey: ULBHGKXUHYSORN-MRXNPFEDSA-N
SMILES: CC(C=C(C(Br)=C1)F)=C1NS(=O)(C2=C(C=C(C=C2)NS(=O)(C3=CC(Cl)=CC(Cl)=C3)=O)CN4[C@@H](COCC4)C)=O
Biological Activity: MDL-811 is a selective allosteric activator of SIRT6 with an EC50 of 5.7 μM. MDL-811 possesses anti-inflammatory, antitumor, and neuroprotective activities. MDL-811 can be used for the research of diseases such as colorectal cancer and ischemic stroke[1][2].
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MDL-811 | 99.68% | MDL-811 is a selective allosteric activator of SIRT6 with an EC50 of 5.7 μM. MDL-811 possesses anti-inflammatory, antitumor, and neuroprotective activities. MDL-811 can be used for the research of diseases such as colorectal cancer and ischemic stroke. | ||||||||||||||||||||
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References
- [1]. Jialin Shang, et al. Small-molecule activating SIRT6 elicits therapeutic effects and synergistically promotes anti-tumor activity of vitamin D3 in colorectal cancer. Theranostics. 2020 Apr 27;10(13):5845-5864. [Content Brief]
- [2]. He T, et al. A novel SIRT6 activator ameliorates neuroinflammation and ischemic brain injury via EZH2/FOXC1 axis. Acta Pharm Sin B. 2021 Mar;11(3):708-726. [Content Brief]
