2286261-72-9
Chemical Structure
PARP10-IN-1
- CAS No.: 2286261-72-9
- Formula:C16H13F3N2O
- Molecular Weight:306.28
IUPAC Name: 5-methyl-6-(2-(trifluoromethyl)pyridin-4-yl)-3,4-dihydroisoquinolin-1(2H)-one
InChIKey: ORKVHLCVQDSOAL-UHFFFAOYSA-N
SMILES: O=C1NCCC2=C1C=CC(C3=CC(C(F)(F)F)=NC=C3)=C2C
Biological Activity: PARP10-IN-1 is a PARP10 inhibitor with an IC50 of 1.8 μM, 2.7 μM, and >10-fold selectivity over most PARP family members, excluding PARP7 and PARP16.PARP10-IN-1 inhibits PARP10-mediated mono-ADP-ribosylation, including auto-MARylation of PARP10 and MARylation of its protein targets.PARP10-IN-1 is membrane permeable and inhibits PARP10-dependent MARylation in human embryonic kidney cells.PARP10-IN-1 can be used for the research of cancer[1].
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PARP10-IN-1 | PARP10-IN-1 is a PARP10 inhibitor with an IC50 of 1.8 μM, 2.7 μM, and >10-fold selectivity over most PARP family members, excluding PARP7 and PARP16.PARP10-IN-1 inhibits PARP10-mediated mono-ADP-ribosylation, including auto-MARylation of PARP10 and MARylation of its protein targets.PARP10-IN-1 is membrane permeable and inhibits PARP10-dependent MARylation in human embryonic kidney cells.PARP10-IN-1 can be used for the research of cancer. | |||||||||||||||||||||
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