23795-03-1
Chemical Structure
Probenecid sodium
- CAS No.: 23795-03-1
- Formula:C13H18NNaO4S
- Molecular Weight:307.34
IUPAC Name: (E)-4-chloro-N-((dimethylamino)methylene)-2-fluorobenzamide
InChIKey: QCCCFHDTBTUDEA-UHFFFAOYSA-M
SMILES: O=C(C1=CC=C(S(=O)(N(CCC)CCC)=O)C=C1)O[Na]
Biological Activity: Probenecid sodium is an orally active, blood-brain barrier-permeable Pannexin 1 channel inhibitor. Probenecid sodium exhibits anti-inflammatory, antiviral, and neuroprotective activities. Probenecid sodium can be used in research related to multiple sclerosis, focal cerebral ischemic injury, influenza virus infection, and nephropathy[1][2][3][4].
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Probenecid sodium | 99.37% | Probenecid sodium is an orally active, blood-brain barrier-permeable Pannexin 1 channel inhibitor. Probenecid sodium exhibits anti-inflammatory, antiviral, and neuroprotective activities. Probenecid sodium can be used in research related to multiple sclerosis, focal cerebral ischemic injury, influenza virus infection, and nephropathy. | ||||||||||||||||||||
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- [1]. Murray J, et al. Probenecid Inhibits Influenza A(H5N1) and A(H7N9) Viruses In Vitro and in Mice. Viruses. 2024;16(1):152. Published 2024 Jan 19. [Content Brief]
- [2]. Baudoux TE, et al. Probenecid prevents acute tubular necrosis in a mouse model of aristolochic acid nephropathy. Kidney Int. 2012;82(10):1105-1113. [Content Brief]
- [3]. Hainz N, et al. Probenecid arrests the progression of pronounced clinical symptoms in a mouse model of multiple sclerosis. Sci Rep. 2017;7(1):17214. Published 2017 Dec 8. [Content Brief]
- [4]. Xiong XX, et al. Probenecid protects against transient focal cerebral ischemic injury by inhibiting HMGB1 release and attenuating AQP4 expression in mice. Neurochem Res. 2014;39(1):216-224. [Content Brief]
Keywords
