2383016-68-8
Chemical Structure
Nrf2 activator-4
- CAS No.: 2383016-68-8
- Formula:C23H24ClF3N2O3
- Molecular Weight:468.90
IUPAC Name: (E)-1-(4-(2-(4-methylpiperazin-1-yl)-2-oxoethoxy)phenyl)-3-(2-(trifluoromethyl)phenyl)prop-2-en-1-one hydrochloride
InChIKey: MLBFDNAGDZEBHA-YGCVIUNWSA-N
SMILES: O=C(C1=CC=C(C=C1)OCC(N2CCN(CC2)C)=O)/C=C/C3=C(C=CC=C3)C(F)(F)F.Cl
Biological Activity: Nrf2 activator-4 (Compound 20a) is a highly potent, orally active Nrf2 activator with an EC50 of 0.63 µM. Nrf2 activator-4 suppresses reactive oxygen species against oxidative stress in microglia. Nrf2 activator-4 effectively recovers the learning and memory impairment in a scopolamine-induced mouse model[1].
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Nrf2 activator-4 | 98.03% | Nrf2 activator-4 (Compound 20a) is a highly potent, orally active Nrf2 activator with an EC50 of 0.63 µM. Nrf2 activator-4 suppresses reactive oxygen species against oxidative stress in microglia. Nrf2 activator-4 effectively recovers the learning and memory impairment in a scopolamine-induced mouse model. | ||||||||||||||||||||
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Keywords
