1. NF-κB
    Protein Tyrosine Kinase/RTK
  2. Keap1-Nrf2
    ROS
  3. Nrf2 activator-4

Nrf2 activator-4 

Cat. No.: HY-146086
Handling Instructions

Nrf2 activator-4 (Compound 20a) is a highly potent, orally active Nrf2 activator with an EC50 of 0.63 µM. Nrf2 activator-4 suppresses reactive oxygen species against oxidative stress in microglia. Nrf2 activator-4 effectively recovers the learning and memory impairment in a scopolamine-induced mouse model.

For research use only. We do not sell to patients.

Nrf2 activator-4 Chemical Structure

Nrf2 activator-4 Chemical Structure

CAS No. : 2383016-68-8

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Description

Nrf2 activator-4 (Compound 20a) is a highly potent, orally active Nrf2 activator with an EC50 of 0.63 µM. Nrf2 activator-4 suppresses reactive oxygen species against oxidative stress in microglia. Nrf2 activator-4 effectively recovers the learning and memory impairment in a scopolamine-induced mouse model[1].

IC50 & Target

EC50: 0.63 µM (Nrf2)[1]

Molecular Weight

468.90

Formula

C23H24ClF3N2O3

CAS No.
SMILES

O=C(C1=CC=C(C=C1)OCC(N2CCN(CC2)C)=O)/C=C/C3=C(C=CC=C3)C(F)(F)F.Cl

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Nrf2 activator-4
Cat. No.:
HY-146086
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