2407892-15-1
2407892-15-1
Chemical Structure
BMS-332
- CAS No.: 2407892-15-1
- Formula:C29H27F2N5O
- Molecular Weight:499.55
InChIKey: XKXKEJGUONTNBW-RBUKOAKNSA-N
SMILES: CN(C1=CC=C(C#N)N=C1C(N2C[C@@H](C)N(C(C3=CC=C(F)C=C3)C4=CC=C(F)C=C4)C[C@@H]2C)=C5)C5=O
Biological Activity: BMS-332 is a dual DGKα/ζ lipid kinase inhibitor, with IC50s of 5 and 1 nM against DGKα and DGKζ, respectively. BMS-332 enhances the antigen-specific T cell response. BMS-332 reduces the viral load in the liver and spleen when combined with anti-PD-1 in chronic infection models. BMS-332 can be used for the study of T cell immune checkpoint strategy[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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BMS-332 | 99.05% | BMS-332 is a dual DGKα/ζ lipid kinase inhibitor, with IC50s of 5 and 1 nM against DGKα and DGKζ, respectively. BMS-332 enhances the antigen-specific T cell response. BMS-332 reduces the viral load in the liver and spleen when combined with anti-PD-1 in chronic infection models. BMS-332 can be used for the study of T cell immune checkpoint strategy. | ||||||||||||||||||||
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References
Keywords
