HCV-IN-37
HCV-IN-37 (Compound 3d) is a potent inhibitor of HCV. HCV-IN-37 is orally available and long-lasting in rat plasma after oral administration to rats by a single dose of 15 mg/kg. The high potency of active derivative HCV-IN-37 is primarily driven by the inhibitory effect on the virus entry stage.
For research use only. We do not sell to patients.
- CAS No.: 2425804-98-2
- Formula: C31H35F2N5
- Molecular Weight:515.64
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
EC50: 0.005 ± 0.005 μM (HCV)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Huh-7.5 | CC50 |
3.31 μM
Compound: 3d
|
Cytotoxicity against human Huh7.5 cells infected with HCVcc assessed as reduction in cell viability incubated for 96 hrs by MTT assay
Cytotoxicity against human Huh7.5 cells infected with HCVcc assessed as reduction in cell viability incubated for 96 hrs by MTT assay
|
[PMID: 35050619] |
| Huh-7.5 | CC50 |
3.95 μM
Compound: 3d
|
Cytotoxicity against human Huh7.5 cells carrying HCV subgenomic replicons assessed as reduction in cell viability incubated for 96 hrs by MTT assay
Cytotoxicity against human Huh7.5 cells carrying HCV subgenomic replicons assessed as reduction in cell viability incubated for 96 hrs by MTT assay
|
[PMID: 35050619] |
| Huh-7.5 | CC50 |
6.24 μM
Compound: 3d
|
Cytotoxicity against human Huh7.5 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay
Cytotoxicity against human Huh7.5 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay
|
[PMID: 35050619] |
Chemical Information
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CAS No. 2425804-98-2
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Molecular Weight 515.64
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Formula C31H35F2N5
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SMILES
N#CC1=CC=C(N2CCN(C)CCC2)C=C1CN3CCN(C(C4=CC=C(F)C=C4)C5=CC=C(F)C=C5)CC3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)