24613-06-7
Chemical Structure
(R)-Levrazoxane
Synonym(s): (R)-ICRF 186
- CAS No.: 24613-06-7
- Formula:C11H16N4O4
- Molecular Weight:268.27
IUPAC Name: (R)-4,4'-(propane-1,2-diyl)bis(piperazine-2,6-dione)
InChIKey: BMKDZUISNHGIBY-SSDOTTSWSA-N
SMILES: C[C@H](CN(CC(N1)=O)CC1=O)N(CC(N2)=O)CC2=O
Biological Activity: (R)-Levrazoxane ((R)-ICRF 186) is enzymatically hydrolysed to one-ring open intermediates by dihydropyrimidine amidohydrolase (DPHase), which is present in the liver and kidney. The radiosensitizing efficiency of (R)-Levrazoxane towards EMT6 mouse mammary tumour cells is greater than that of Dexrazoxane (HY-B0581). (R)-Levrazoxane is promising for research of liver and kidney related diseases[1].
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(R)-Levrazoxane | (R)-Levrazoxane ((R)-ICRF 186) is enzymatically hydrolysed to one-ring open intermediates by dihydropyrimidine amidohydrolase (DPHase), which is present in the liver and kidney. The radiosensitizing efficiency of (R)-Levrazoxane towards EMT6 mouse mammary tumour cells is greater than that of Dexrazoxane (HY-B0581). (R)-Levrazoxane is promising for research of liver and kidney related diseases. | |||||||||||||||||||||
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Keywords
