2489446-59-3
Chemical Structure
FLT3/ITD-IN-2
- CAS No.: 2489446-59-3
- Formula:C23H26F3N7O2
- Molecular Weight:489.49
IUPAC Name: (R)-N-(4-morpholino-2-(trifluoromethyl)phenyl)-5-(piperidin-3-ylamino)pyrazolo[1,5-a]pyrimidine-3-carboxamide
InChIKey: OVUNCUIZEBAAGC-OAHLLOKOSA-N
SMILES: O=C(C1=C2N=C(C=CN2N=C1)N[C@@H]3CCCNC3)NC4=CC=C(C=C4C(F)(F)F)N5CCOCC5
Biological Activity: FLT3/ITD-IN-2 (Compound 17) is a potent FLT3 internal tandem duplications (FLT3-ITD) inhibitor with IC50 values of 0.3, 0.4 and 1.0 nM against FLT3D835Y, FLT3 and FLT3-ITD, respectively. FLT3/ITD-IN-2 potently inhibits the phosphorylation of FLT3 and displays excellent antiproliferative activities against acute myeloid leukemia cell lines[1].
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FLT3/ITD-IN-2 | FLT3/ITD-IN-2 (Compound 17) is a potent FLT3 internal tandem duplications (FLT3-ITD) inhibitor with IC50 values of 0.3, 0.4 and 1.0 nM against FLT3D835Y, FLT3 and FLT3-ITD, respectively. FLT3/ITD-IN-2 potently inhibits the phosphorylation of FLT3 and displays excellent antiproliferative activities against acute myeloid leukemia cell lines. | |||||||||||||||||||||
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