1. Protein Tyrosine Kinase/RTK
  2. FLT3
  3. FLT3/ITD-IN-2

FLT3/ITD-IN-2 

Cat. No.: HY-144710
Handling Instructions

FLT3/ITD-IN-2 (Compound 17) is a potent FLT3 internal tandem duplications (FLT3-ITD) inhibitor with IC50 values of 0.3, 0.4 and 1.0 nM against FLT3D835Y, FLT3 and FLT3-ITD, respectively. FLT3/ITD-IN-2 potently inhibits the phosphorylation of FLT3 and displays excellent antiproliferative activities against acute myeloid leukemia cell lines.

For research use only. We do not sell to patients.

FLT3/ITD-IN-2 Chemical Structure

FLT3/ITD-IN-2 Chemical Structure

CAS No. : 2489446-59-3

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Description

FLT3/ITD-IN-2 (Compound 17) is a potent FLT3 internal tandem duplications (FLT3-ITD) inhibitor with IC50 values of 0.3, 0.4 and 1.0 nM against FLT3D835Y, FLT3 and FLT3-ITD, respectively. FLT3/ITD-IN-2 potently inhibits the phosphorylation of FLT3 and displays excellent antiproliferative activities against acute myeloid leukemia cell lines[1].

IC50 & Target

IC50: 0.3 nM (FLT3D835Y), 0.4 nM (FLT3), 1.0 nM (FLT3-ITD)[1]

Molecular Weight

489.49

Formula

C23H26F3N7O2

CAS No.
SMILES

O=C(C1=C2N=C(C=CN2N=C1)N[[email protected]@H]3CCCNC3)NC4=CC=C(C=C4C(F)(F)F)N5CCOCC5

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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FLT3/ITD-IN-2
Cat. No.:
HY-144710
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