24916-52-7
Chemical Structure
Spiramycin III
- CAS No.: 24916-52-7
- Formula:C46H78N2O15
- Molecular Weight:899.12
IUPAC Name: (4R,5S,6S,7R,9R,10R,11E,13Z,16R)-6-(((2S,3R,4R,5S,6R)-5-(((2S,4R,5S,6S)-4,5-dihydroxy-4,6-dimethyltetrahydro-2H-pyran-2-yl)oxy)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-10-(((2R,5S,6R)-5-(dimethylamino)-6-methyltetrahydro-2H-pyran
InChIKey: HSZLKTCKAYXVBX-JRXTWLFLSA-N
SMILES: C[C@@H]1[C@H](CC[C@@H](O1)O[C@@H]2[C@@H](C[C@@H]([C@@H]([C@@H](OC)[C@@H](CC(O[C@H](C)C/C=C\C=C\2)=O)OC(CC)=O)O[C@@H]3O[C@@H]([C@H]([C@@H]([C@H]3O)N(C)C)O[C@@H]4O[C@H]([C@@H]([C@@](C)(C4)O)O)C)C)CC=O)C)N(C)C
Biological Activity: Spiramycin III (SPMIII) is a main component of Spiramycin. Spiramycin (HY-100593) is a macrolide antibiotic produced by Streptomyces ambofaciens with against bacteria and Toxoplasma gondii activities, and also has antiparasitic effect[1][2].
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Spiramycin III | Spiramycin III (SPMIII) is a main component of Spiramycin. Spiramycin (HY-100593) is a macrolide antibiotic produced by Streptomyces ambofaciens with against bacteria and Toxoplasma gondii activities, and also has antiparasitic effect. | |||||||||||||||||||||
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- [1]. X R Xu, et al. [Determination of partition coefficient by high-pressure liquid chromatography. I. Determination of partition coefficient of cinnamic acids and related compounds by reversed-phase high-pressure liquid chromatography (author's transl)]. Yao Xue Xue Bao. 1979;14(4):246-52. [Content Brief]
- [2]. Nguyen HC, et al. Post-PKS tailoring steps of the spiramycin macrolactone ring in Streptomyces ambofaciens. Antimicrob Agents Chemother. 2013 Aug;57(8):3836-42. [Content Brief]
Keywords
