25683-07-2
25683-07-2
Chemical Structure
Pyoluteorin
- CAS No.: 25683-07-2
- Formula:C11H7Cl2NO3
- Molecular Weight:272.08
IUPAC Name: (4,5-dichloro-1H-pyrrol-2-yl)(2,6-dihydroxyphenyl)methanone
InChIKey: JPGWTZORMBTNMF-UHFFFAOYSA-N
SMILES: O=C(C1=C(C=CC=C1O)O)C2=CC(Cl)=C(N2)Cl
Biological Activity: Pyoluteorin is an antibiotic that inhibits Oomycete fungi, including the plant pathogen Pythium ultimum, and suppresses plant diseases caused by this fungus[1]. Pyoluteorin induces human triple-negative breast cancer MDA-MB-231 cells apoptosis in vitro. Pyoluteorin can be used for the research of human triple-negative breast cancer[2].
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Pyoluteorin | 99.90% | Pyoluteorin is an antibiotic that inhibits Oomycete fungi, including the plant pathogen Pythium ultimum, and suppresses plant diseases caused by this fungus. Pyoluteorin induces human triple-negative breast cancer MDA-MB-231 cells apoptosis in vitro. Pyoluteorin can be used for the research of human triple-negative breast cancer. | ||||||||||||||||||||
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References
- [1]. B Nowak-Thompson, et al. Characterization of the pyoluteorin biosynthetic gene cluster of Pseudomonas fluorescens Pf-5. J Bacteriol. 1999 Apr;181(7):2166-74. [Content Brief]
- [2]. Ting Ding, et al. Pyoluteorin induces cell cycle arrest and apoptosis in human triple-negative breast cancer cells MDA-MB-231. J Pharm Pharmacol. 2020 Jul;72(7):969-978. [Content Brief]
