2569296-51-9
2569296-51-9
Chemical Structure
MIPS-21335
- CAS No.: 2569296-51-9
- Formula:C24H21N7O5
- Molecular Weight:487.47
InChIKey: BWAYXCQNGYCPDU-UHFFFAOYSA-N
SMILES: COC1=C2N=C(N3CCN=C3C2=CC=C1OCC4=CC([N+]([O-])=O)=CC=C4)NC(C5=CN=C(C=C5)N)=O
Biological Activity: MIPS-21335 is a PI3KC2α inhibitor with an IC50 of 7 nM. MIPS-21335 also inhibits PI3KC2β, p110α, p110β and p110δ, with IC50 values of 43, 140, 386 and 742 nM, respectively. MIPS-21335 has antithrombotic effect. MIPS-21335 can be used for the researches of cardiovascular disease and metabolic disease, such as thrombosis and hyperlipidemia[1][2].
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MIPS-21335 | 99.61% | MIPS-21335 is a PI3KC2α inhibitor with an IC50 of 7 nM. MIPS-21335 also inhibits PI3KC2β, p110α, p110β and p110δ, with IC50 values of 43, 140, 386 and 742 nM, respectively. MIPS-21335 has antithrombotic effect. MIPS-21335 can be used for the researches of cardiovascular disease and metabolic disease, such as thrombosis and hyperlipidemia. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.66
HY-12030PIK-90 -
Similarity Score 0.64
HY-15346RCopanlisib (Standard) -
Similarity Score 0.64
HY-182086Copanlisib-NH -
Similarity Score 0.64
HY-141690API3K-IN-19 hydrochloride -
Similarity Score 0.63
HY-15346ACopanlisib dihydrochloride -
Similarity Score 0.62
HY-100886BAY1082439 -
Similarity Score 0.50
![7-Methoxy-8-(3-morpholin-4-ylpropoxy)-2,3-dihydroimidazo[1,2-c]quinazolin-5-amine Chemical Structure](//file.medchemexpress.com/product_pic/hy-w366582.gif)
HY-W3665827-Methoxy-8-(3-morpholin-4-ylpropoxy)-2,3-dihydroimidazo[1,2-c]quinazolin-5-amine -
Similarity Score 0.46
HY-U00040PAF-AN-1 -
Similarity Score 0.45
HY-163278Lck-IN-2 -
Explore the MedChemAI to find more analogs
![7-Methoxy-8-(3-morpholin-4-ylpropoxy)-2,3-dihydroimidazo[1,2-c]quinazolin-5-amine Chemical Structure](http://file.medchemexpress.com/product_pic/hy-w366582.gif)
References
- [1]. Selvadurai MV, et al. Disrupting the platelet internal membrane via PI3KC2α inhibition impairs thrombosis independently of canonical platelet activation. Sci Transl Med. 2020 Jul 22;12(553):eaar8430. [Content Brief]
- [2]. Setiabakti NM, et al. PI3KC2α inhibition is antithrombotic in blood from hypercholesterolemic mice. J Thromb Haemost. 2024 Jan;22(1):249-254. [Content Brief]
