269730-03-2
269730-03-2
Chemical Structure
RPI-1
- CAS. Nr.: 269730-03-2
- Formula:C17H15NO4
- Molecular Weight:297.31
IUPAC Name: (Z)-3-(4-hydroxybenzylidene)-5,6-dimethoxyindolin-2-one
InChIKey: JGSMCYNBVCGIHC-QPEQYQDCSA-N
SMILES: O=C1NC2=C(C=C(OC)C(OC)=C2)/C1=C/C3=CC=C(O)C=C3
Biological Activity: RPI-1 is a specific, orally available 2-indolinone Ret tyrosine kinase inhibitor. RPI-1 inhibits proliferation, Ret tyrosine phosphorylation, Ret protein expression, and the activation of PLCgamma, ERKs and AKT in human medullary thyroid carcinoma TT cells. Antitumor activity[1].
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RPI-1 | 98.47% | RPI-1 is a specific, orally available 2-indolinone Ret tyrosine kinase inhibitor. RPI-1 inhibits proliferation, Ret tyrosine phosphorylation, Ret protein expression, and the activation of PLCgamma, ERKs and AKT in human medullary thyroid carcinoma TT cells. Antitumor activity. | ||||||||||||||||||||
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References
Keywords
