2728667-27-2
2728667-27-2
Chemical Structure
Zongertinib
Synonym(s): BI 1810631
- CAS No.: 2728667-27-2
- Formula:C29H29N9O2
- Molecular Weight:535.60
InChIKey: YSGNGFPNTLERCR-UHFFFAOYSA-N
SMILES: O=C(NC1CCN(CC1)C2=NC=C3N=CN=C(C3=N2)NC4=CC=C(C(C)=C4)OC5=CC(N=CN6C)=C6C=C5)C=C
Biological Activity: Zongertinib (BI 1810631) is a potent and selective HER2 and EGFR tyrosine kinase inhibitor with IC50 values of 13 nM and 579 nM, respectively. Zongertinib has antitumor activity and can be used in the study of multiple solid tumors[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Zongertinib | 99.74% | Zongertinib (BI 1810631) is a potent and selective HER2 and EGFR tyrosine kinase inhibitor with IC50 values of 13 nM and 579 nM, respectively. Zongertinib has antitumor activity and can be used in the study of multiple solid tumors. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.83
HY-150024BI-4142 -
Similarity Score 0.67
HY-150023BI-1622 -
Similarity Score 0.56
HY-163420HER2-IN-16 -
Similarity Score 0.54
HY-103438ABIBU1361 dihydrochloride -
Similarity Score 0.53
HY-103438BIBU1361 -
Similarity Score 0.53
HY-163419HER2-IN-18 -
Similarity Score 0.52
HY-177895IAM1363 -
Similarity Score 0.52
HY-163421hERG-IN-2 -
Similarity Score 0.52
HY-177009Tucatinib analog B -
Explore the MedChemAI to find more analogs
References
- [1]. WHO Drug Informat ion - World Health Organization (WHO).
- [2]. Wilding Birgit, et al. Synthesis of diazino-pyrimidines as anticancer agents: World Intellectual Property Organization, WO2021213800. 2021-10-28.
- [3]. Li S, et al. Emerging Targeted Therapies in Advanced Non-Small-Cell Lung Cancer. Cancers (Basel). 2023 May 24;15(11):2899. [Content Brief]
