3000567-45-0
3000567-45-0
Chemical Structure
RORγ/DHODH-IN-2
- CAS No.: 3000567-45-0
- Formula:C22H16D2ClF4N5O2
- Molecular Weight:497.87
InChIKey: MRJLIFZIFUEXQG-KBMKNGFXSA-N
SMILES: ClC1=C(C(F)=CC=C1)C2=NOC(C3=C(N(N=C3)C([2H])(CC(C)(C)O)[2H])C(F)(F)F)=C2C4=NC=CC=N4
Biological Activity: RORγ/DHODH-IN-2 (Compound 1311) is an orally active dual inhibitor of RORγ/DHODH with IC50 values of 11.9 nM and 90 nM, respectively. RORγ/DHODH-IN-2 exhibits antiviral activity by inhibiting the activity of SARS-CoV-2, HCMV, HAdV5, and MPXV, with IC50 values of 27 nM, 20 nM, 9.1 nM, and 1.8 nM, respectively[1].
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RORγ/DHODH-IN-2 | RORγ/DHODH-IN-2 (Compound 1311) is an orally active dual inhibitor of RORγ/DHODH with IC50 values of 11.9 nM and 90 nM, respectively. RORγ/DHODH-IN-2 exhibits antiviral activity by inhibiting the activity of SARS-CoV-2, HCMV, HAdV5, and MPXV, with IC50 values of 27 nM, 20 nM, 9.1 nM, and 1.8 nM, respectively. | |||||||||||||||||||||
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Izumerogant | 99.95% | Izumerogant (IMU-935) is an orally active RORγ/DHODH dual inhibitor with IC50s of 10 and 98 nM against RORγ and DHODH. Izumerogant efficiently blocks the replication of SARS-CoV-2, HCMV and HAdV5 with EC50 values between 3.6 and 17 nM. Izumerogant can be used for researching antiviral properties. | ||||||||||||||||||||
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References
Keywords
