3032392-39-2

GK444 Chemical Structure
3032392-39-2

Chemical Structure

GK444

  • CAS No.: 3032392-39-2
  • Formula:C33H32N4O4
  • Molecular Weight:548.63

InChIKey: QGJOQSWDMMVMFK-PMERELPUSA-N

SMILES: O=C([C@@H]1CCC(N1CC2=CC=CC=C2)=O)NCC3=CC=C(OCC4=CC=C(C(NC5=CC=CC=C5N)=O)C=C4)C=C3

Biological Activity: GK444 (Compound 15a) is a HDAC1/2 inhibitor (IC50: 100 and 92 nM for HDAC1/2 respectively). GK444 inhibits Caco-2 cells with IC50 of 4.1 μM. GK444 also reduces TGF-β1 induced COL1A1 mRNA levels in primary normal human lung fibroblasts. GK444 inhibits Bleomycin (HY-108345)-induced lung fibrosis in mice[1].

Cat. No. Product Name Purity Description Pricing
HY-155328 		GK444 GK444 (Compound 15a) is a HDAC1/2 inhibitor (IC50: 100 and 92 nM for HDAC1/2 respectively). GK444 inhibits Caco-2 cells with IC50 of 4.1 μM. GK444 also reduces TGF-β1 induced COL1A1 mRNA levels in primary normal human lung fibroblasts. GK444 inhibits Bleomycin (HY-108345)-induced lung fibrosis in mice.
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