306-94-5
306-94-5
Chemical Structure
Perfluorodecalin
Synonym(s): PP 5; Perfluorodecahydronaphthalene
- CAS No.: 306-94-5
- Formula:C10F18
- Molecular Weight:462.08
IUPAC Name: perfluorodecahydronaphthalene
InChIKey: UWEYRJFJVCLAGH-UHFFFAOYSA-N
SMILES: FC12C(F)(F)C(F)(F)C(F)(F)C(F)(F)C1(F)C(F)(F)C(F)(F)C(F)(F)C2(F)F
Biological Activity: Perfluorodecalin liquids are largrly used in vitreoretinal surgery. Perfluorodecalin with tamponade lasting more than two days is detrimental to the retina in the case of rabbit. Perfluorodecalin can be used for the research of giant retinal tears[1][2]. Perfluorodecalin is a non-toxic, non-flammable, thermally stable, non-bio-accumulating O2-carrier and used as artificial blood[3]. Perfluorodecalin enhances bone regeneration and cell viability[4][5].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Perfluorodecalin | 98.0% | Perfluorodecalin liquids are largrly used in vitreoretinal surgery. Perfluorodecalin with tamponade lasting more than two days is detrimental to the retina in the case of rabbit. Perfluorodecalin can be used for the research of giant retinal tears. Perfluorodecalin is a non-toxic, non-flammable, thermally stable, non-bio-accumulating O2-carrier and used as artificial blood. Perfluorodecalin enhances bone regeneration and cell viability. | ||||||||||||||||||||
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Perfluorodecalin (Standard) | ≥98% | Perfluorodecalin (Standard) is the analytical standard of Perfluorodecalin (HY-108298). This product is intended for research and analytical applications. Perfluorodecalin liquids are largrly used in vitreoretinal surgery. Perfluorodecalin with tamponade lasting more than two days is detrimental to the retina in the case of rabbit. Perfluorodecalin can be used for the research of giant retinal tears. Perfluorodecalin is a non-toxic, non-flammable, thermally stable, non-bio-accumulating O2-carrier and used as artificial blood. Perfluorodecalin enhances bone regeneration and cell viability. | ||||||||||||||||||||
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Perfluorohexane | 98.2% | Perfluorohexane (AF-0150) is a perfluorocarbon. Perfluorohexane is also an enhancer of high-intensity focused ultrasound (HIFU) therapy. Perfluorohexane increases HO-1 and IL-10. Perfluorohexane exerts an antioxidant effect. Perfluorohexane alleviates lung injury induced by LPS (HY-D1056A1). Perfluorohexane improves the efficiency and precision of HIFU and reduces damage to surrounding normal tissues. Perfluorohexane can be used in the study of acute lung injury. | ||||||||||||||||||||
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Perflubron | 99.54% | Perflubron (Perfluorooctyl bromide) is a contrast medium for magnetic resonance imaging and sonography. Perflubron inhibits chemokine expression and NF-κB activation. Perflubron can be emulsified with egg phospholipids (EYP) and shows exceptionally fast excretion characteristics. Perflubron has anti-inflammatory, antiviral and cytoprotective effects. | ||||||||||||||||||||
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Epifriedelanol | 99.69% | Epifriedelanol is a triterpenoid found in the root bark of Ulmus davidiana. Epifriedelanol induces apoptosis in DU145 cells. Epifriedelanol has antitumor and anti-inflammatory activities. Epifriedelanol inhibits cellular senescence in human primary cells. | ||||||||||||||||||||
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Friedelinol | Friedelinol is a Triterpenoids product that can be isolated from the herbs of Celastrus stylosus Wall.. | |||||||||||||||||||||
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Friedelin (Standard) | ≥98% | Friedelin (Standard) is the analytical standard of Friedelin. This product is intended for research and analytical applications. Friedelin is isolated from isolated from the leaves of Maytenus ilicifolia(Mart). Friedelin is a noncompetitive inhibitor of CYP3A4 with IC50 and Kivalues of 10.79 ?μM and 6.16? μM, respectively. Friedelin is also a competitive inhibitor of CYP2E1 with IC50 and Ki values of 22.54? μM and 18.02 μM, respectively. | ||||||||||||||||||||
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6:2 Fluorotelomer alcohol | 99.96% | 6:2 Fluorotelomer alcohol (6:2 FTOH) is an orally active, blood-brain barrier-permeable modulator of cyclin D1 and ETS1. 6:2 Fluorotelomer alcohol downregulates cyclin D1 expression, upregulates ETS1 via the TNF-α/ERK 1/2 pathway, impairs mitochondrial membrane potential and respiratory function, increases reactive oxygen species levels, disrupts calcium homeostasis and activates endoplasmic reticulum stress markers, and induces cell proliferation inhibition and endothelial-mesenchymal transition. Furthermore, 6:2 Fluorotelomer alcohol induces morphological abnormalities in zebrafish embryos and liver developmental damage, while disrupting the brain immune microenvironment in mice, causing systemic toxicity and delayed pup maturation in CD-1 mice. 6:2 Fluorotelomer alcohol also induces cortical neuron apoptosis, glial cell activation, synaptic abnormalities, colonic barrier damage, intestinal dysbiosis and autism spectrum disorder-like symptoms in mice. 6:2 Fluorotelomer alcohol shows no mutagenic, clastogenic, primary skin/eye irritation or skin sensitizing effects, exhibits no selective reproductive toxicity in CD-1 mice, and is classified as GHS Category 4 for acute oral toxicity. 6:2 Fluorotelomer alcohol can be used in studies of neurodevelopmental disorders and autism spectrum disorders. | ||||||||||||||||||||
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2H,2H,3H,3H-Perfluorooctanoic acid | 99.83% | 2H,2H,3H,3H-Perfluorooctanoic acid (4,4,5,5,6,6,7,7,8,8,8-Undecafluorooctanoic acid) is a biological molecule. | ||||||||||||||||||||
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Perfluorohexyloctane | 98.0% | Perfluorohexyloctane (NOV03), a semifluorinated alkane, reduces tear film instability in Meibomian gland dysfunction and evaporative dry eye disease. Perfluorohexyloctane is a long-term tamponade agent. Perfluorohexyloctane increases tear film breakup time and lipid layer thickness. | ||||||||||||||||||||
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References
- [1]. Orzalesi N, et al. Experimental short-term tolerance to perfluorodecalin in the rabbit eye: a histopathological study. Curr Eye Res. 1998;17(8):828-835. [Content Brief]
- [2]. Bourke RD, et al. Experimental long-term vitreous replacement with purified and nonpurified perfluorodecalin. Am J Ophthalmol. 1994;118(3):403-404. [Content Brief]
- [3]. Spahn DR. Blood substitutes. Artificial oxygen carriers: perfluorocarbon emulsions. Crit Care. 1999;3(5):R93-7. [Content Brief]
- [4]. Tamimi F, et al., Perfluorodecalin and bone regeneration. Eur Cell Mater. 2013 Jan 2;25:22-36. [Content Brief]
- [5]. Rodriguez-Brotons A, et al., Comparison of Perfluorodecalin and HEMOXCell as Oxygen Carriers for Islet Oxygenation in an In Vitro Model of Encapsulation. Tissue Eng Part A. 2016 Dec;22(23-24):1327-1336. [Content Brief]
