3083634-54-9
3083634-54-9
Chemical Structure
NF764
- CAS No.: 3083634-54-9
- Formula:C22H20F3NO3
- Molecular Weight:403.39
InChIKey: IRMQALGXGFYYJW-VAWYXSNFSA-N
SMILES: FC(F)(F)C1=C(C2N(C(/C=C/C(C3=CC=CC=C3)=O)=O)CCC2)C=C(OC)C=C1
Biological Activity: NF764 is a CTNNB1 degrader. When used in combination with USP38 knockdown, NF764 exhibits synergistic anti-tumor activity and induces Ferroptosis. NF764 can be used in studies related to colorectal cancer and melanoma[1][2].
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NF764 | 98.44% | NF764 is a CTNNB1 degrader. When used in combination with USP38 knockdown, NF764 exhibits synergistic anti-tumor activity and induces Ferroptosis. NF764 can be used in studies related to colorectal cancer and melanoma. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.53
HY-146086Nrf2 activator-4 -
Similarity Score 0.52
HY-100688ML390 -
Similarity Score 0.52
HY-135664hDHODH-IN-5 -
Similarity Score 0.51
HY-171705KMS99220 -
Similarity Score 0.50
HY-W854844A(E)-JP-2-196 TFA -
Similarity Score 0.50
HY-10049CP 122721 -
Similarity Score 0.50
HY-179505OPN-9652 -
Similarity Score 0.49
HY-10049ACP 122721 hydrochloride -
Similarity Score 0.49
HY-1243452-Trifluoromethyl-2'-methoxychalcone -
Explore the MedChemAI to find more analogs
References
- [1]. Gowans FA, et al. Covalent Degrader of the Oncogenic Transcription Factor β-Catenin. J Am Chem Soc. 2024 Jun 6:10.1021/jacs.4c05174. [Content Brief]
- [2]. Chu X, et al. USP38 regulates autophagy-dependent ferroptosis by deubiquitinating CTNNB1 in melanoma. International journal of biological macromolecules. 2026 Feb;341(Pt 2):149611. [Content Brief]
