1. Metabolic Enzyme/Protease
    Cell Cycle/DNA Damage
  2. Dihydroorotate Dehydrogenase
    DNA/RNA Synthesis
  3. DHODH-IN-7

DHODH-IN-7 

Cat. No.: HY-135664
Handling Instructions

DHODH-IN-7 is a human dihydroorotate dehydrogenase (DHODH) inhibitor, with an IC50 of 0.91 μM. DHODH-IN-7 induces differentiation in acute myeloid leukemia.

For research use only. We do not sell to patients.

DHODH-IN-7 Chemical Structure

DHODH-IN-7 Chemical Structure

CAS No. : 2029049-77-0

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Description

DHODH-IN-7 is a human dihydroorotate dehydrogenase (DHODH) inhibitor, with an IC50 of 0.91 μM. DHODH-IN-7 induces differentiation in acute myeloid leukemia[1].

In Vitro

The lysozyme-GFPER-HoxA9 murine cell line (ER-HOX-GFP) and the THP1 and U937 human AML cell lines were cultured with compounds in a 4-day differentiation assay. DHODH-IN-7 shows EC50s of 3.6, 2.7, and 2.5 μM for ER-HOX-GFP, THP1 and U937 human AML cell lines, respectively[1].

Molecular Weight

390.40

Formula

C₂₁H₂₁F₃N₂O₂

CAS No.

2029049-77-0

SMILES

O=C(NCCC(N[[email protected]@H]1CCCC2=C1C=CC=C2)=O)C3=CC=C(C(F)(F)F)C=C3

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Keywords:

DHODH-IN-7Dihydroorotate DehydrogenaseDNA/RNA SynthesisDHODHdifferentiation,acutemyeloidleukemiaU937cellsTHP-1Inhibitorinhibitorinhibit

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