313671-26-0
313671-26-0
Chemical Structure
BMS-986121
- CAS No.: 313671-26-0
- Formula:C15H9Cl2N3O2S
- Molecular Weight:366.22
IUPAC Name: N-(2,6-dichlorophenyl)-4-(4-nitrophenyl)thiazol-2-amine
InChIKey: AOCLKIVPDLQCOF-UHFFFAOYSA-N
SMILES: O=[N+](C1=CC=C(C2=CSC(NC3=C(Cl)C=CC=C3Cl)=N2)C=C1)[O-]
Biological Activity: BMS-986121 is a positive allosteric modulator (PAM) of the μ opioid receptor extracted from patent WO2014107344. BMS-986121 is built on a chemical scaffold representing a new chemotype for μ receptor PAMs[1][2][3].
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BMS-986121 | 99.96% | BMS-986121 is a positive allosteric modulator (PAM) of the μ opioid receptor extracted from patent WO2014107344. BMS-986121 is built on a chemical scaffold representing a new chemotype for μ receptor PAMs. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.71
HY-13822SKI II -
Similarity Score 0.70
HY-180460SCPI-1 -
Similarity Score 0.69
HY-148318CK2α-IN-1 -
Similarity Score 0.67
HY-121488GP130 receptor agonist-1 -
Similarity Score 0.66
HY-114775RCGD423 -
Similarity Score 0.65
HY-141890BAZ1A-IN-1 -
Similarity Score 0.64
HY-100746STF-62247 -
Similarity Score 0.63
HY-134476NF-κΒ activator 1 -
Similarity Score 0.62
HY-148180Antimycobacterial agent-4 -
Explore the MedChemAI to find more analogs
References
- [1]. Burford NT, et al. Discovery of positive allosteric modulators and silent allosteric modulators of the μ-opioid receptor. Proc Natl Acad Sci U S A. 2013;110(26):10830-10835. [Content Brief]
- [2]. WO2014107344
- [3]. Bisignano P, et al. Ligand-Based Discovery of a New Scaffold for Allosteric Modulation of the μ-Opioid Receptor. J Chem Inf Model. 2015;55(9):1836-1843. [Content Brief]
