CK2α-IN-1
Based on 1 Customer Validation
CK2α-IN-1 (compound 2) is a selective CK2α inhibitor (IC50=7.0 µM; Ki=1.6 µM) that exhibits a non-ATP-competitive mode of action. CK2α-IN-1 exhibits good potential for anticancer studies.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity : 98.34%
- CAS No.: 443747-52-2
- 화학식: C16H11N3O4S
- 분자량:341.34
-
보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
용액&용해도
- 순도&문서
- References
-
Help & FAQs
-
HY-50855B
Silmitasertib sodium saltCasein Kinase 2 Inhibitor -
HY-15479
TTP 22Casein Kinase Inhibitor -
HY-115519
(E/Z)-GO289CK2 Inhibitor -
HY-145260
BRD4/CK2-IN-1BRD4-CK2 Dual Inhibitor -
HY-148328
CK2-IN-4CK2 Inhibitor -
HY-15490
PF-670462 dihydrochlorideCK1δ/ε Inhibitor -
HY-N3127
OrobolCK1ε Inhibitor -
HY-15704
LH846Casein Kinase Inhibitor -
HY-120675
SSTC3CK1α Activator -
HY-120084
BTX161CK1α Molecular Glue Degrader -
HY-148455
Casein kinase 1δ-IN-3CK1d Inhibitor -
HY-156666
Casein kinase 1δ-IN-8Casein kinase 1δ Inhibitor
Biological Activity
제품 설명
IC50 & Target
IC50:7.0 µM (CK2α)[1].
Chemical Information
-
CAS No. 443747-52-2
-
Appearance Solid
-
분자량 341.34
-
화학식 C16H11N3O4S
-
Color Light yellow to yellow
-
SMILES
O=C(C1=CC(NC2=NC(C3=CC([N+]([O-])=O)=CC=C3)=CS2)=CC=C1)O
-
선적
Room temperature in continental US; may vary elsewhere.
-
보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
용액&용해도
In Vitro:
DMSO : 100 mg/mL (292.96 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
-
-
-
-
Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
-
%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
-
%+
-
+%Tween-80 + +
-
%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
순도&문서
-
Data Sheet (272 KB)
-
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
-
Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.9296 mL | 14.6482 mL | 29.2963 mL | 73.2408 mL |
| 5 mM | 0.5859 mL | 2.9296 mL | 5.8593 mL | 14.6482 mL | |
| 10 mM | 0.2930 mL | 1.4648 mL | 2.9296 mL | 7.3241 mL | |
| 15 mM | 0.1953 mL | 0.9765 mL | 1.9531 mL | 4.8827 mL | |
| 20 mM | 0.1465 mL | 0.7324 mL | 1.4648 mL | 3.6620 mL | |
| 25 mM | 0.1172 mL | 0.5859 mL | 1.1719 mL | 2.9296 mL | |
| 30 mM | 0.0977 mL | 0.4883 mL | 0.9765 mL | 2.4414 mL | |
| 40 mM | 0.0732 mL | 0.3662 mL | 0.7324 mL | 1.8310 mL | |
| 50 mM | 0.0586 mL | 0.2930 mL | 0.5859 mL | 1.4648 mL | |
| 60 mM | 0.0488 mL | 0.2441 mL | 0.4883 mL | 1.2207 mL | |
| 80 mM | 0.0366 mL | 0.1831 mL | 0.3662 mL | 0.9155 mL | |
| 100 mM | 0.0293 mL | 0.1465 mL | 0.2930 mL | 0.7324 mL |
CK2α-IN-1 Related Classifications
HY-148318 Related Classifications
Powered by Bioz