3344-12-5
3344-12-5
Chemical Structure
Isomalathion
- CAS. Nr.: 3344-12-5
- Formula:C10H19O6PS2
- Molecular Weight:330.36
IUPAC Name: diethyl 2-((methoxy(methylthio)phosphoryl)thio)succinate
InChIKey: LPQDGVLVYVULMX-UHFFFAOYSA-N
SMILES: O=C(CC(C(OCC)=O)SP(OC)(SC)=O)OCC
Biological Activity: Isomalathion is an isomer and impurity of Malathion (HY-B0943). Isomalathion inhibits Carboxyesterase and AChE, with an IC50 value of 3.2 μM against bovine acetylcholinesterase. Isomalathion moderately reduces CYP1A2 transcript levels, increases CYP2B6 transcript levels, and induces dose-dependent DNA damage. Malathion is an organophosphorus insecticide[1][2][3].
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Isomalathion | Isomalathion is an isomer and impurity of Malathion (HY-B0943). Isomalathion inhibits Carboxyesterase and AChE, with an IC50 value of 3.2 μM against bovine acetylcholinesterase. Isomalathion moderately reduces CYP1A2 transcript levels, increases CYP2B6 transcript levels, and induces dose-dependent DNA damage. Malathion is an organophosphorus insecticide. | |||||||||||||||||||||
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References
- [1]. Josse R, et al. Impact of isomalathion on malathion cytotoxicity and genotoxicity in human HepaRG cells. Chemico-biological interactions. 2014 Feb 25;209:68-76.
- [2]. Krstić DZ, et al. Inhibition of AChE by malathion and some structurally similar compounds. Journal of enzyme inhibition and medicinal chemistry. 2008 Aug;23(4):562-73.
- [3]. Błasiak J, et al. In vitro studies on the genotoxicity of the organophosphorus insecticide malathion and its two analogues. Mutation research. 1999 Sep 30;445(2):275-83.
