3546-03-0
3546-03-0
Chemical Structure
Cyamemazine
- CAS No.: 3546-03-0
- Formula:C19H21N3S
- Molecular Weight:323.46
IUPAC Name: 10-(3-(dimethylamino)-2-methylpropyl)-10H-phenothiazine-2-carbonitrile
InChIKey: SLFGIOIONGJGRT-UHFFFAOYSA-N
SMILES: CN(C)CC(C)CN1C2=C(C=CC(C#N)=C2)SC3=CC=CC=C31
Biological Activity: Cyamemazine is a neuroleptic agent that contains the phenothiazine chromophore. Cyamemazine is often used as an anxiolytic. Cyamemazine is a potent 5-HT3 (Ki of 12 nM), 5-HT2A (Ki = 1.5 nM) and 5-HT2C (Ki of 75 nM) receptors antagonist with antipsychotic activity[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Cyamemazine | 99.47% | Cyamemazine is a neuroleptic agent that contains the phenothiazine chromophore. Cyamemazine is often used as an anxiolytic. Cyamemazine is a potent 5-HT3 (Ki of 12 nM), 5-HT2A (Ki = 1.5 nM) and 5-HT2C (Ki of 75 nM) receptors antagonist with antipsychotic activity. | ||||||||||||||||||||
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Cyamemazine (Standard) | ≥98% | Cyamemazine (Standard) is the analytical standard of Cyamemazine. This product is intended for research and analytical applications. Cyamemazine is a neuroleptic agent that contains the phenothiazine chromophore. Cyamemazine is often used as an anxiolytic. Cyamemazine is a potent 5-HT3 (Ki of 12 nM), 5-HT2A (Ki = 1.5 nM) and 5-HT2C (Ki of 75 nM) receptors antagonist with antipsychotic activity. | ||||||||||||||||||||
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Cyamemazine-d6 | Cyamemazine-d6 is the deuterium labeled Cyamemazine. Cyamemazine is a neuroleptic agent that contains the phenothiazine chromophore. Cyamemazine is often used as an anxiolytic. Cyamemazine is a potent 5-HT3 (Ki of 12 nM), 5-HT2A (Ki = 1.5 nM) and 5-HT2C (Ki of 75 nM) receptors antagonist with antipsychotic activity. | |||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.83
HY-127069Methiomeprazine -
Similarity Score 0.83
HY-12752Alimemazine -
Similarity Score 0.83
HY-19489R(±)-Levomepromazine (Standard) -
Similarity Score 0.83
HY-B1693Levomepromazine -
Similarity Score 0.82
HY-B1693ALevomepromazine hydrochloride -
Similarity Score 0.79
HY-19489S3(±)-Levomepromazine-d3 -
Similarity Score 0.78
HY-19489S1(Rac)-Levomepromazine-d3 hydrochloride -
Similarity Score 0.77
HY-169325A(R)-ACE-OH -
Similarity Score 0.76
HY-A0243Aceprometazine -
Explore the MedChemAI to find more analogs
References
- [1]. Bourin M, et al. Preclinical and clinical pharmacology of cyamemazine: anxiolytic effects and prevention of alcohol and benzodiazepine withdrawal syndrome. CNS Drug Rev. 2004 Fall;10(3):219-29. [Content Brief]
- [2]. Vendrell-Criado V, et al. Photobehavior of the antipsychotic drug cyamemazine in a supramolecular gel protective environment. J Photochem Photobiol B. 2020 Jan;202:111686. [Content Brief]
