37271-16-2
37271-16-2
Chemical Structure
Sennoside C
- CAS No.: 37271-16-2
- Formula:C42H40O19
- Molecular Weight:848.76
IUPAC Name: 4,4'-dihydroxy-2'-(hydroxymethyl)-10,10'-dioxo-5,5'-bis((3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-9,9',10,10'-tetrahydro-[9,9'-bianthracene]-2-carboxylic acid
InChIKey: ZFWOUNNKSHIAFK-UHFFFAOYSA-N
SMILES: OC(C(O)C1O)C(OC1CO)OC2=CC=CC(C(C(C3=CC(CO)=CC(O)=C3C4=O)C5=C4C(OC(C(C(O)C6O)O)OC6CO)=CC=C5)C7=CC(C(O)=O)=CC(O)=C87)=C2C8=O
Biological Activity: Sennoside C is an orally active component of the traditional Chinese medicine Sennae Folium. Sennoside C can bind to human lysozyme and inhibit its amyloid fibrosis (IC50: 186.20 μM). Sennoside C has certain purgative activity. Sennoside C can be used in the research of diarrhea and anti-amyloid related diseases[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Sennoside C | 99.63% | Sennoside C is an orally active component of the traditional Chinese medicine Sennae Folium. Sennoside C can bind to human lysozyme and inhibit its amyloid fibrosis (IC50: 186.20 μM). Sennoside C has certain purgative activity. Sennoside C can be used in the research of diarrhea and anti-amyloid related diseases. | ||||||||||||||||||||
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Sennoside C (Standard) | ≥98% | Sennoside C (Standard) is the analytical standard of Sennoside C (HY-N1972). This product is intended for research and analytical applications. Sennoside C is an orally active component of the traditional Chinese medicine Sennae Folium. Sennoside C can bind to human lysozyme and inhibit its amyloid fibrosis (IC50: 186.20 μM). Sennoside C has certain purgative activity. Sennoside C can be used in the research of diarrhea and anti-amyloid related diseases. | ||||||||||||||||||||
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Sennoside A (Standard) | 98.81% | Sennoside A (Standard) is the analytical standard of Sennoside A. This product is intended for research and analytical applications. Sennoside A is an anthraquinone glycoside, found in Senna (Cassia angustifolia). Sennoside A is a HIV-1 inhibitor effective on HIV-1 replication. | ||||||||||||||||||||
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Sennoside B | 99.23% | Sennoside B is a potent and orally active platelet-derived growth factor (PDGF) inhibitor. Sennoside B inhibits cell proliferation and the expression of phosphorylation of PDGFR-β, STAT-5, AKT and ERK induced by PDGF-BB. Sennoside B shows gastroprotective activities. Sennoside B has the potential for the research of gastritis. | ||||||||||||||||||||
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Cascaroside B | Cascaroside B is a flavonoid and antifungal agent found in the Pseudomonas aeruginosa Ld-08. | |||||||||||||||||||||
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Cascaroside C | Cascaroside C is an anthraquinone compound. Cascaroside C can be isolated from the roots of Rheum emodi and Rhamnus purshianus DC. | |||||||||||||||||||||
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Sikokianin E | Sikokianin E is a biflavonone compound that can be isolated from Coreopsis tinctoria. | |||||||||||||||||||||
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Sennoside | Sennoside is an orally active apoptosis inducer and stimulant laxative, found in Senna (Cassia angustifolia). Sennoside induces overexpression of wild-type p53 and p21/WAF as part of pathways mediating colonic epithelial cell apoptosis. Sennoside stimulates colonic peristalsis, reverses net water, sodium, chloride absorption to secretion and enhances potassium and calcium secretion. Sennoside increases paracellular permeability to small molecules, accelerates colon transit and softens fecal pellets. Sennoside can be used for the research of constipation, melanosis coli, and colorectal cancer. | |||||||||||||||||||||
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Emodin-8-O-beta-gentiobioside | Emodin-8-O-beta-gentiobioside is a natural product. | |||||||||||||||||||||
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Sennoside D (Standard) | ≥98% | Sennoside D (Standard) is the analytical standard of Sennoside D. This product is intended for research and analytical applications. Sennoside D is an anthraquinone glycoside, found in leaves and pods of Senna (Cassia angustifolia). | ||||||||||||||||||||
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Chrysophanol triglucoside | Chrysophanol triglucoside is an anthraquinone isolated from Cassia obtusifolia, inhibits protein tyrosine phosphatases 1B (PTP1B) and α-glucosidase with IC50s of 80.17 and 197.06 µM, respectively. Chrysophanol triglucoside has the potential for diabetes research. | |||||||||||||||||||||
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Emodin-1-O-β-gentiobioside | Emodin-1-O-β-gentiobioside is an anthraquinone. | |||||||||||||||||||||
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References
- [1]. Rama Reddy NR, et al. Next Generation Sequencing and Transcriptome Analysis Predicts Biosynthetic Pathway of Sennosides from Senna (Cassia angustifolia Vahl.), a Non-Model Plant with Potent Laxative Properties. PLoS One. 2015 Jun 22;10(6):e0129422. [Content Brief]
- [2]. Gao W, et al. Inhibition behavior of Sennoside A and Sennoside C on amyloid fibrillation of human lysozyme and its possible mechanism. Int J Biol Macromol. 2021 May 1;178:424-433. [Content Brief]
- [3]. Kisa K, et al. Potentiating effect of sennoside C on purgative activity of sennoside A in mice. Planta Med. 1981 Jul;42(3):302-3. [Content Brief]
