3989-97-7
3989-97-7
Chemical Structure
Valylleucine
Synonym(s): Val-Leu; H-Val-Leu-OH
- CAS No.: 3989-97-7
- Formula:C11H22N2O3
- Molecular Weight:230.30
InChIKey: XCTHZFGSVQBHBW-IUCAKERBSA-N
SMILES: CC(C)[C@H](N)C(N[C@H](C(O)=O)CC(C)C)=O
Biological Activity: Valylleucine (Val-Leu; H-Val-Leu-OH) is a branched-chain dipeptide that can enter cells independently via bacterial dipeptide transport systems, and is hydrolyzed by dipeptidases to release Val and Leu. Valylleucine, as a model peptide, has its α-amino pK determined to be 7.90 by combining FDNB reaction kinetics with potentiometric titration[1][2].
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Valylleucine | Valylleucine (Val-Leu; H-Val-Leu-OH) is a branched-chain dipeptide that can enter cells independently via bacterial dipeptide transport systems, and is hydrolyzed by dipeptidases to release Val and Leu. Valylleucine, as a model peptide, has its α-amino pK determined to be 7.90 by combining FDNB reaction kinetics with potentiometric titration. | |||||||||||||||||||||
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References
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[1]. Hill RJ, Davis RW. The pK of specific groups of proteins: I. The α-AMINO group of the α chain of human CO-hemoglobin. Journal of Biological Chemistry. 1967 May 10;242(9):2005-12.
- [2]. Smulson ME, et al. O-methylthreonine inhibition of growth and of threonine deaminase in Escherichia coli. J Bacteriol. 1967;94(6):1890-1895. [Content Brief]
