41303-74-6
41303-74-6
Chemical Structure
N-Desmethyl Galanthamine
Synonym(s): Norgalanthamine
- CAS No.: 41303-74-6
- Formula:C16H19NO3
- Molecular Weight:273.33
IUPAC Name: (4aS,6R,8aS)-3-methoxy-4a,5,9,10,11,12-hexahydro-6H-benzo[2,3]benzofuro[4,3-cd]azepin-6-ol
InChIKey: AIXQQSTVOSFSMO-RBOXIYTFSA-N
SMILES: O[C@H]1C=C[C@@]23CCNCC4=CC=C(OC)C(O[C@@]3([H])C1)=C24
Biological Activity: N-Desmethyl Galanthamine (N-Norgalanthamine) is a metabolite of Galanthamine (HY-76299). N-Desmethyl Galanthamine is an EeAChE inhibitor with an IC50 of 2.76 μM. N-Desmethyl Galanthamine can be used in the research of Alzheimer's disease[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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N-Desmethyl Galanthamine | 99.60% | N-Desmethyl Galanthamine (N-Norgalanthamine) is a metabolite of Galanthamine (HY-76299). N-Desmethyl Galanthamine is an EeAChE inhibitor with an IC50 of 2.76 μM. N-Desmethyl Galanthamine can be used in the research of Alzheimer's disease. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.82
HY-76299RGalanthamine (Standard) -
Similarity Score 0.82
HY-N7265Epi-galantamine -
Similarity Score 0.81
HY-A0009Galanthamine hydrobromide -
Similarity Score 0.78
HY-N7263Galanthamine N-Oxide -
Similarity Score 0.78
HY-185199Nornarwedine -
Similarity Score 0.76
HY-76299S2Galanthamine-d3 hydrochloride -
Similarity Score 0.73
HY-76299S1Galanthamine-O-methyl-d3 -
Similarity Score 0.72
HY-131413O-Desmethyl Galanthamine -
Similarity Score 0.68
HY-76299SGalanthamine-d6 -
Explore the MedChemAI to find more analogs
References
- [1]. Bachus R, et al. The O-demethylation of the antidementia drug galanthamine is catalysed by cytochrome P450 2D6. Pharmacogenetics. 1999;9(6):661-668. [Content Brief]
- [2]. Melanie-Jayne R. Howes, et al. Acetylcholinesterase inhibitors of natural origin. International Journal of Research in Pharmaceutical and Biomedical Sciences 3(SI 1):67-86.
- [3]. Cahlíková L, et al. Recent Progress on Biological Activity of Amaryllidaceae and Further Isoquinoline Alkaloids in Connection with Alzheimer's Disease. Molecules. 2021 Aug 29;26(17):5240. [Content Brief]
