4330-99-8
Chemical Structure
Alimemazine hemitartrate
Synonym(s): Trimeprazine hemitartrate
- CAS No.: 4330-99-8
- Formula:C18H22N2S.1/2C4H6O6
- Molecular Weight:373.49
SMILES: CC(CN(C)C)CN1C2=CC=CC=C2SC3=CC=CC=C13.O=C(O)[C@H](O)[C@@H](O)C(O)=O
Biological Activity: Alimemazine hemitartrate (Trimeprazine hemitartrate) is an antagonist of the histamine (HA) receptor that can be taken orally and also acts as a partial agonist at other GPCR receptors. Alimemazine hemitartrate has effects that include anti-serotonin, antispasmodic, antihistamine, sedation, hypnotic, antiviral, and anti-nausea properties. Alimemazine hemitartrate promotes the growth of pancreatic β-cells in mice and improves diabetes in mice[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Alimemazine hemitartrate | 99.49% | Alimemazine hemitartrate (Trimeprazine hemitartrate) is an antagonist of the histamine (HA) receptor that can be taken orally and also acts as a partial agonist at other GPCR receptors. Alimemazine hemitartrate has effects that include anti-serotonin, antispasmodic, antihistamine, sedation, hypnotic, antiviral, and anti-nausea properties. Alimemazine hemitartrate promotes the growth of pancreatic β-cells in mice and improves diabetes in mice. | ||||||||||||||||||||
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Alimemazine hemitartrate (Standard) | ≥98% | Alimemazine hemitartrate (Standard) is the analytical standard of Alimemazine hemitartrate. This product is intended for research and analytical applications. Alimemazine hemitartrate is a phenothiazine derivative that is generally used as an antipruritic agent and also a hemagglutinin (HA)-receptor antagonist. | ||||||||||||||||||||
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Alimemazine-d6 | 99.55% | Alimemazine-d6 is deuterium labeled Alimemazine, which is an antihistamine. | ||||||||||||||||||||
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References
- [1]. Singh B, et al. Bioanalytical method development and validation of alimemazine in human plasma by LC-MS/MS and its application in bioequivalence studies. J Pharm Bioallied Sci. 2013 Oct;5(4):257-64. [Content Brief]
- [2]. Kuznetsova A, et al. Trimeprazine increases IRS2 in human islets and promotes pancreatic β cell growth and function in mice. JCI Insight. 2016;1(3). [Content Brief]
- [3]. Mei Hashizume, et al. Phenothiazines inhibit SARS-CoV-2 cell entry via a blockade of spike protein binding to neuropilin-1. Antiviral Research. Volume 209, January 2023, 105481
