433690-62-1
Chemical Structure
AA41612
- CAS No.: 433690-62-1
- Formula:C12H15Cl2NO3S
- Molecular Weight:324.23
IUPAC Name: 1-((2,5-dichloro-4-methoxyphenyl)sulfonyl)piperidine
InChIKey: FEMVYIQDVGQFBA-UHFFFAOYSA-N
SMILES: O=S(N1CCCCC1)(C2=CC(Cl)=C(OC)C=C2Cl)=O
Biological Activity: AA41612 is a melanopsin (Opn4) inhibitor with an IC50 of 15.8 nM, a Ki of 0.43 nM, and a Kd of 0.28 nM. AA41612 competes with retinal for binding to melanopsin, blocks melanopsin activation, and inhibits melanopsin-mediated phototransduction processes without affecting rod- and cone-mediated responses. AA41612 attenuates light-induced melanopsin photocurrents, reduces light-induced cytoplasmic calcium elevation, and weakens high-irradiance pupillary light reflex in mice with induced classical photoreceptor degeneration. AA41612 can be used in studies related to migraine and photophobia[1][2].
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AA41612 | 99.78% | AA41612 is a melanopsin (Opn4) inhibitor with an IC50 of 15.8 nM, a Ki of 0.43 nM, and a Kd of 0.28 nM. AA41612 competes with retinal for binding to melanopsin, blocks melanopsin activation, and inhibits melanopsin-mediated phototransduction processes without affecting rod- and cone-mediated responses. AA41612 attenuates light-induced melanopsin photocurrents, reduces light-induced cytoplasmic calcium elevation, and weakens high-irradiance pupillary light reflex in mice with induced classical photoreceptor degeneration. AA41612 can be used in studies related to migraine and photophobia. | ||||||||||||||||||||
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[1]. Jones KA, et al. Small-molecule antagonists of melanopsin-mediated phototransduction. Nat Chem Biol. 2013 Oct;9(10):630-5.
[Content Brief] -
[2]. Jain V, et al. Classical Photoreceptors Are Primarily Responsible for the Pupillary Light Reflex in Mouse. PLoS One. 2016 Jun 13;11(6):e0157226.
[Content Brief]
Keywords
