4444-42-2
4444-42-2
Chemical Structure
Desmethylnortriptyline
- CAS No.: 4444-42-2
- Formula:C18H19N
- Molecular Weight:249.35
IUPAC Name: 3-(10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)propan-1-amine
InChIKey: PTQFRALDEONNOA-UHFFFAOYSA-N
SMILES: NCC/C=C1C2=CC=CC=C2CCC3=CC=CC=C\13
Biological Activity: Desmethylnortriptyline is a metabolite of Nortriptyline (HY-118620). Nortriptyline is a tricyclic antidepressant and the main active metabolite of Amitriptyline (HY-B0527) , and is used to relieve the symptoms of depression[1][2].
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Desmethylnortriptyline | 99.95% | Desmethylnortriptyline is a metabolite of Nortriptyline (HY-118620). Nortriptyline is a tricyclic antidepressant and the main active metabolite of Amitriptyline (HY-B0527) , and is used to relieve the symptoms of depression. | ||||||||||||||||||||
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Desmethylnortriptyline (Standard) | ≥98% | Desmethylnortriptyline (Standard) is the analytical standard of Desmethylnortriptyline (HY-100651). This product is intended for research and analytical applications. Desmethylnortriptyline is a metabolite of Amitriptyline (HY-B0527) and Nortriptyline (HY-118620). Desmethylnortriptylineinhibits serotonin and noradrenaline uptake, antagonizes acetylcholine-induced contraction. Desmethylnortriptyline can be used for the research of depression. | ||||||||||||||||||||
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References
- [1]. Burch JE, et al. Determination of desmethyl nortriptyline in plasma by gas chromatography before and after treatment with salicylaldehyde. J Chromatogr. 1983 May 13;274:350-4. [Content Brief]
- [2]. Shimoda K, et al. The impact of CYP2C19 and CYP2D6 genotypes on metabolism of amitriptyline in Japanese psychiatric patients. J Clin Psychopharmacol. 2002 Aug;22(4):371-8. [Content Brief]
