461426-41-5
Chemical Structure
10-Formylfolic acid-d4
- CAS No.: 461426-41-5
- Formula:C20H15D4N7O7
- Molecular Weight:473.43
IUPAC Name: (4-(N-((2-amino-4-oxo-4,8-dihydropteridin-6-yl)methyl)formamido)benzoyl-2,3,5,6-d4-2,3,5,6-d4)-L-glutamic acid
InChIKey: UGWUWNVTCLDEOG-MNZXJJDISA-N
SMILES: O=C1C2=NC(CN(C3=C([2H])C([2H])=C(C([2H])=C3[2H])C(N[C@H](C(O)=O)CCC(O)=O)=O)C=O)=CNC2=NC(N)=N1
Biological Activity: 10-Formylfolic acid-d4 is the deuterated-labeled 10-Formylfolic acid (HY-124350). 10-Formylfolic acid is a potent inhibitor of dihydrofolate reductase, with an IC50 of 80 nM against the rat enzyme. 10-Formylfolic acid also acts as an orally active folate source and a growth factor for specific bacteria. 10-Formylfolic acid supports growth and increases plasma folate levels; its absorption and metabolism patterns are similar to those of folic acid, but its liver retention is slightly higher. It exhibits high folate activity in microbial assays, serves as a growth factor for Enterococcus faecalis and Lactobacillus casei, aids folate nutrient supply, and may exert cell regulatory functions[1][2][3].
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10-Formylfolic acid-d4 | 10-Formylfolic acid-d4 is the deuterated-labeled 10-Formylfolic acid (HY-124350). 10-Formylfolic acid is a potent inhibitor of dihydrofolate reductase, with an IC50 of 80 nM against the rat enzyme. 10-Formylfolic acid also acts as an orally active folate source and a growth factor for specific bacteria. 10-Formylfolic acid supports growth and increases plasma folate levels; its absorption and metabolism patterns are similar to those of folic acid, but its liver retention is slightly higher. It exhibits high folate activity in microbial assays, serves as a growth factor for Enterococcus faecalis and Lactobacillus casei, aids folate nutrient supply, and may exert cell regulatory functions. | |||||||||||||||||||||
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10-Formylfolic acid (Standard) | ≥98% | 10-Formylfolic acid (Standard) is the analytical standard of 10-Formylfolic acid (HY-124350). This product is intended for research and analytical applications. 10-Formylfolic acid is a potent inhibitor of dihydrofolate reductase, with an IC50 of 80 nM against the rat enzyme. 10-Formylfolic acid also acts as an orally active folate source and a growth factor for specific bacteria. 10-Formylfolic acid supports growth and increases plasma folate levels; its absorption and metabolism patterns are similar to those of folic acid, but its liver retention is slightly higher. It exhibits high folate activity in microbial assays, serves as a growth factor for Enterococcus faecalis and Lactobacillus casei, aids folate nutrient supply, and may exert cell regulatory functions. | ||||||||||||||||||||
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10-Formylfolic acid | 94.49% | 10-Formylfolic acid is a potent inhibitor of dihydrofolate reductase, with an IC50 of 80 nM against the rat enzyme. 10-Formylfolic acid also acts as an orally active folate source and a growth factor for specific bacteria. 10-Formylfolic acid supports growth and increases plasma folate levels; its absorption and metabolism patterns are similar to those of folic acid, but its liver retention is slightly higher. It exhibits high folate activity in microbial assays, serves as a growth factor for Enterococcus faecalis and Lactobacillus casei, aids folate nutrient supply, and may exert cell regulatory functions. | ||||||||||||||||||||
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References
- [1]. Gregory JF III, et al. Biological activity of the folacin oxidation products 10‑formylfolic acid and 5‑methyl‑5,6‑dihyrofolic acid. J Agric Food Chem. 1984;32(6):1337‑1342.
- [2]. D'Urso-Scott M, et al. Formation of 10-formylfolic acid, a potent inhibitor of dihydrofolate reductase, in rat liver slices incubated with folic acid. Proceedings of the National Academy of Sciences of the United States of America. 1974 Jul;71(7):2736-9. [Content Brief]
- [3]. Ashokkumar K, et al. Identification and determination of naturally occurring folates in grains of rice (Oryza sativa L.) by UPLC-MS/MS analysis. Natural product research. 2018 Jul;32(14):1733-1737.
