466-26-2
Chemical Structure
Neoline
Synonym(s): Bullatine B
- CAS No.: 466-26-2
- Formula:C24H39NO6
- Molecular Weight:437.57
IUPAC Name: (3S,6S,7R,7aR,8S,9S,10S,11aR,13R,14R)-1-ethyl-10,13-dimethoxy-3-(methoxymethyl)tetradecahydro-11aH-3,6a,12-(epiethane[1,1,2]triyl)-7,9-methanonaphtho[2,3-b]azocine-6,8,11a-triol
InChIKey: XRARAKHBJHWUHW-XPGJPNGISA-N
SMILES: O[C@@H]1C23[C@@]4([H])[C@](COC)(CN(CC)C2C([C@]5(O)[C@]6([H])[C@@]3([H])C[C@@]([C@@H](OC)C5)([H])[C@@H]6O)[C@@H]4OC)CC1
Biological Activity: Neoline (Bullatine B) is the active ingredient of the active ingredient (PA), which can be used to cure the disease. Neoline Flow Suppression Nav1.7 Electrical Flow Control (VGSC), improve diabetes mechanical pain sensitivity. Neoline has a list of compounds that can be used, research on its use, and the quality of its processing during processing in pain[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Neoline | 98.0% | Neoline (Bullatine B) is the active ingredient of the active ingredient (PA), which can be used to cure the disease. Neoline Flow Suppression Nav1.7 Electrical Flow Control (VGSC), improve diabetes mechanical pain sensitivity. Neoline has a list of compounds that can be used, research on its use, and the quality of its processing during processing in pain. | ||||||||||||||||||||
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Talatisamine | 99.77% | Talatisamine is an orally active cyclophilin D activator isolated from the roots of Aconitum carmichaeli Debx. Talatisamine exerts biological functions by activating cyclophilin D, inhibiting Ca2+-dependent opening of the mitochondrial permeability transition pore (mPTP) (IC50=78 μM), and blocking delayed rectifier K+ channels (IC50=146 μM). Talatisamine possesses both antioxidant and membrane-stabilizing properties, effectively inhibits lipid peroxidation and protects mitochondrial membrane function. Talatisamine exhibits multiple activities including antiarrhythmic, hypotensive, anti-inflammatory, anticancer and neuroprotective effects. Talatisamine finds applications in the research of ischemic diseases, rheumatoid arthritis, inflammation-related diseases and Alzheimer's disease. |
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10-Hydroxyneoline | 10-Hydroxyneoline is a diterpene alkaloid compound isolated from Aconitum fukutomei. | |||||||||||||||||||||
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14-O-Acetylneoline | 14-O-Acetylneoline is a natural product. | |||||||||||||||||||||
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Senbusine A | Senbusine A (compound 4) is a diterpenic alkaloid found in the dried roots of Aconitum carmichaeli from China. Senbusine A acts as an intermediate in the biosynthesis of aconitine. | |||||||||||||||||||||
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Chasmanine | Chasmanine is an alkaloid isolated from the roots of Aconitum crassicaule. | |||||||||||||||||||||
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6-Epiforsticine | 6-Epiforsticine is a C19-diterpenoid alkaloid found in Aconitum hemsleyanum var. pengzhouense and A. kuzsnezoffii. | |||||||||||||||||||||
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Fuziline (Standard) | ≥98% | Fuziline (Standard) is the analytical standard of Fuziline. This product is intended for research and analytical applications. Fuziline is a alkaloid isolated from the lateral roots of Aconitum carmichaelii. | ||||||||||||||||||||
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Neolinine | Neolinine is a diterpenoid alkaloid that can be isolated from the aerial parts of Aconitum carmichaeli. | |||||||||||||||||||||
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Carmichaenine B | Carmichaenine B is a Alkaloids product that can be isolated from the aerial parts of Aconitum carmichaeli.. | |||||||||||||||||||||
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Isotalatizidine | Isotalatizidine is a norditerpenoid alkaloid found in Aconitum napellus ssp. neomontanum. | |||||||||||||||||||||
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References
- [1]. Tanimura Y, et al. Neoline is the active ingredient of processed aconite root against murine peripheral neuropathic pain model, and its pharmacokinetics in rats.J Ethnopharmacol. 2019 Sep 15;241:111859. [Content Brief]
- [2]. Nakatani Y, Negoro K, Yamauchi M, et al. Neoline, an active ingredient of the processed aconite root in Goshajinkigan formulation, targets Nav1.7 to ameliorate mechanical hyperalgesia in diabetic mice. J Ethnopharmacol. 2020;259:112963. [Content Brief]
