470-40-6
Chemical Structure
Thujopsene
- CAS. Nr.: 470-40-6
- Formula:C15H24
- Molecular Weight:204.35
IUPAC Name: (1aS,4aS,8aS)-2,4a,8,8-tetramethyl-1,1a,4,4a,5,6,7,8-octahydrocyclopropa[d]naphthalene
InChIKey: WXQGPFZDVCRBME-QEJZJMRPSA-N
SMILES: CC1(C)[C@]23[C@](C3)([H])C(C)=CC[C@]2(C)CCC1
Biological Activity: Thujopsene is the inhibitor for cytochrome P450, that inhibits CYP2B6, CYP3A4, CYP2C19, CYP2C8, CYP2C9 with IC50s of 1.3, 12.6, 13.6, 29.8, and 44.9 μM, respectively. Thujopsene binds to PKM2, inhibits the metabolism pathway of cancer cell, induces apoptosis in MKN45, thereby exhibiting antitumor efficacy. Thujopsene exhibits anti-termite and antifungal activities through autoxidation[1][2][3].
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Thujopsene | Thujopsene is the inhibitor for cytochrome P450, that inhibits CYP2B6, CYP3A4, CYP2C19, CYP2C8, CYP2C9 with IC50s of 1.3, 12.6, 13.6, 29.8, and 44.9 μM, respectively. Thujopsene binds to PKM2, inhibits the metabolism pathway of cancer cell, induces apoptosis in MKN45, thereby exhibiting antitumor efficacy. Thujopsene exhibits anti-termite and antifungal activities through autoxidation. | |||||||||||||||||||||
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- [1]. Jeong HU, et al., Inhibitory effects of cedrol, β-cedrene, and thujopsene on cytochrome P450 enzyme activities in human liver microsomes. J Toxicol Environ Health A. 2014;77(22-24):1522-32. [Content Brief]
- [2]. Nagata T, et al. Evaporated fraction of thujopsene from Thujopsis dolabrata starves cancer cells via PKM2 Anti-tumor effect of the volatile components of Thujopsis dolabrata[J]. 2023.
- [3]. Mukai A, et al. Antitermite and antifungal activities of thujopsene natural autoxidation products[J]. European Journal of Wood and Wood Products, 2019, 77: 311-317.
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