4707-47-5
Chemical Structure
Atraric acid
Synonym(s): Methyl atrarate
- CAS No.: 4707-47-5
- Formula:C10H12O4
- Molecular Weight:196.20
IUPAC Name: methyl 2,4-dihydroxy-3,6-dimethylbenzoate
InChIKey: UUQHKWMIDYRWHH-UHFFFAOYSA-N
SMILES: O=C(OC)C1=C(C)C=C(O)C(C)=C1O
Biological Activity: Atraric acid (Methyl atrarate) is a specific androgen receptor (AR) antagonist with anti-inflammatory and anticancer effects. Atraric acid represses the expression of the endogenous prostate specific antigen gene in both LNCaP and C4-2 cells. Atraric acid can also inhibit the synthesis of NO and cytokine, and suppress the MAPK-NFκB signaling pathway. Atraric acid can be used to research prostate diseases and inflammatory diseases[1][2].
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Atraric acid | 99.97% | Atraric acid (Methyl atrarate) is a specific androgen receptor (AR) antagonist with anti-inflammatory and anticancer effects. Atraric acid represses the expression of the endogenous prostate specific antigen gene in both LNCaP and C4-2 cells. Atraric acid can also inhibit the synthesis of NO and cytokine, and suppress the MAPK-NFκB signaling pathway. Atraric acid can be used to research prostate diseases and inflammatory diseases. | ||||||||||||||||||||
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Atraric acid (Standard) | ≥98% | Atraric acid (Standard) is the analytical standard of Atraric acid. This product is intended for research and analytical applications. Atraric acid (Methyl atrarate) is a specific androgen receptor (AR) antagonist with anti-inflammatory and anticancer effects. Atraric acid represses the expression of the endogenous prostate specific antigen gene in both LNCaP and C4-2 cells. Atraric acid can also inhibit the synthesis of NO and cytokine, and suppress the MAPK-NFκB signaling pathway. Atraric acid can be used to research prostate diseases and inflammatory diseases. | ||||||||||||||||||||
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Similarity Score 0.88
HY-N3270Methyl orsellinate -
Similarity Score 0.88
HY-1298243-Methyl orsellinic acid -
Similarity Score 0.83
HY-W573700Methyl everninate -
Similarity Score 0.81
HY-W000427Ethyl Orsellinate -
Similarity Score 0.81
HY-W144096Methyl 2,4,6-trihydroxybenzoate -
Similarity Score 0.80
HY-N2010Methyl gallate -
Similarity Score 0.80
HY-W101041RMethyl 2-hydroxy-6-methylbenzoate (Standard) -
Similarity Score 0.80
HY-N6669RMethyl 3-O-methylgallate (Standard) -
Similarity Score 0.80
HY-W017378RTrimethylhydroquinone (Standard) -
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References
- [1]. Papaioannou M, et al. The natural compound atraric acid is an antagonist of the human androgen receptor inhibiting cellular invasiveness and prostate cancer cell growth. J Cell Mol Med. 2009 Aug;13(8B):2210-2223. [Content Brief]
- [2]. Roell D, Baniahmad A. The natural compounds atraric acid and N-butylbenzene-sulfonamide as antagonists of the human androgen receptor and inhibitors of prostate cancer cell growth. Mol Cell Endocrinol. 2011 Jan 30;332(1-2):1-8. [Content Brief]
