480-54-6
Chemical Structure
Retrorsine
- CAS No.: 480-54-6
- Formula:C18H25NO6
- Molecular Weight:351.39
IUPAC Name: (5R,6S,9a1R,14aR,Z)-3-ethylidene-6-hydroxy-6-(hydroxymethyl)-5-methyl-3,4,5,6,9,9a1,11,13,14,14a-decahydro-[1,6]dioxacyclododecino[2,3,4-gh]pyrrolizine-2,7-dione
InChIKey: BCJMNZRQJAVDLD-CQRYIUNCSA-N
SMILES: O=C(O[C@]1([H])CCN2[C@]1([H])C(COC([C@](CO)(O)[C@H](C)C/3)=O)=CC2)C3=C/C
Biological Activity: Retrorsine is a naturally occurring toxic pyrrolizidine alkaloid. Retrorsine can bind with DNA and inhibits the proliferative capacity of hepatocytes. Retrorsine can be used for the research of hepatocellular injury[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Retrorsine | 99.91% | Retrorsine is a naturally occurring toxic pyrrolizidine alkaloid. Retrorsine can bind with DNA and inhibits the proliferative capacity of hepatocytes. Retrorsine can be used for the research of hepatocellular injury. | ||||||||||||||||||||
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- [1]. F J Cubero, et al. Hepatic proliferation in Gunn rats transplanted with hepatocytes: effect of retrorsine and tri-iodothyronine. Cell Prolif. 2005 Jun;38(3):137-46. [Content Brief]
- [2]. S Laconi, et al. Liver regeneration in response to partial hepatectomy in rats treated with retrorsine: a kinetic study. J Hepatol. 1999 Dec;31(6):1069-74. [Content Brief]
Keywords
