485-71-2
485-71-2
Chemical Structure
Cinchonidine
Synonym(s): α-Quinidine
- CAS No.: 485-71-2
- Formula:C19H22N2O
- Molecular Weight:294.39
IUPAC Name: (R)-quinolin-4-yl((1S,2S,4S,5R)-5-vinylquinuclidin-2-yl)methanol
InChIKey: KMPWYEUPVWOPIM-KODHJQJWSA-N
SMILES: C=C[C@H]1C[N@](CC[C@H]1C2)[C@]2([H])[C@H](O)C3=CC=NC4=CC=CC=C34
Biological Activity: Cinchonidine (α-Quinidine) is a cinchona alkaloid found in Cinchona officinalis and Gongronema latifolium. A building block used in asymmetric synthesis in organic chemistry. Weak inhibitor of serotonin transporter (SERT) with Kis of 330, 4.2, 36, 196, 15 μM for dSERT, hSERT, hSERT I172M, hSERT S438T, hSERT Y95F, respectively. Antimalarial activities[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Cinchonidine | 99.62% | Cinchonidine (α-Quinidine) is a cinchona alkaloid found in Cinchona officinalis and Gongronema latifolium. A building block used in asymmetric synthesis in organic chemistry. Weak inhibitor of serotonin transporter (SERT) with Kis of 330, 4.2, 36, 196, 15 μM for dSERT, hSERT, hSERT I172M, hSERT S438T, hSERT Y95F, respectively. Antimalarial activities. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Cinchonidine (Standard) | 99.58% | Cinchonidine (Standard) is the analytical standard of Cinchonidine. This product is intended for research and analytical applications. Cinchonidine (α-Quinidine) is a cinchona alkaloid found in Cinchona officinalis and Gongronema latifolium. A building block used in asymmetric synthesis in organic chemistry. Weak inhibitor of serotonin transporter (SERT) with Kis of 330, 4.2, 36, 196, 15 μM for dSERT, hSERT, hSERT I172M, hSERT S438T, hSERT Y95F, respectively. Antimalarial activities. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Ep vinyl quinidine | Ep vinyl quinidine (3-Epiquinine) is an epi-vinyl stereoisomer of Quinidine. Quinidine is an antiarrhythmic agent. Quinidine is a potent, orally active, selective cytochrome P450db inhibitor. Quinidine is also a K+ channel blocker with an IC50 of 19.9 μM. Quinidine can be used for malaria research. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Quinidine (15% dihydroquinidine) (Standard) | 99.22% | Quinidine (15% dihydroquinidine) (Standard) is the analytical standard of Quinidine (15% dihydroquinidine) (HY-B1751). This product is intended for research and analytical applications. Quinidine (15% dihydroquinidine) is an orally active antiarrhythmic agent. Quinidine (15% dihydroquinidine) reduces the expression level of P-gp, inhibits P-gp-mediated efflux, increases the intracellular accumulation of P-gp substrates, induces PARP cleavage and Caspase-3 activation, and elevates the proportion of Apoptotic cells at the sub-G1 phase. Quinidine (15% dihydroquinidine) exerts sustained block and open-channel block effects on IK(f). Quinidine (15% dihydroquinidine) alters the urinary metabolic ratio of Amphetamine, modulates the Pentylenetetrazol-induced seizure threshold, and regulates the anticonvulsant effect of Dextromethorphan. Quinidine (15% dihydroquinidine) can be used in studies related to uterine sarcoma and seizures. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Quinine (Standard) | 95.79% | Quinine (Standard) is the analytical standard of Quinine (HY-D0143). This product is intended for research and analytical applications. Quinineis an orally active alkaloid extracted from cinchona bark, possessing various biological activities including antimalarial, antidengue virus (DENV), and anticancer properties. Quinine is a potassium channel inhibitor that inhibits WT mouse Slo3 (KCa5.1) channel currents evoked by voltage pulses to +100 mV with an IC50 of 169 μM. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Cinchonine hydrochloride | Cinchonine hydrochloride ((8R,9S)-Cinchonine hydrochloride) is a natural alkaloid present in Cinchona bark, with antimalarial activity. Cinchonine hydrochloride activates endoplasmic reticulum (ER) stress-induced apoptosis in human liver cancer cells. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
(8α,9R)-10,11-dihydro-Cinchonan-9-ol (Standard) | ≥98% | (8α,9R)-10,11-dihydro-Cinchonan-9-ol (Standard) is the analytical standard of (8α,9R)-10,11-dihydro-Cinchonan-9-ol. This product is intended for research and analytical applications. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Hydrocinchonine | 98.33% | Hydrocinchonine (Dihydrocinchonine) is a multidrug resistance (MDR)-reversal agent. Hydrocinchonine directly inhibits the function and expression of P-gp, which is the mechanism by which it reverses MDR. Hydrocinchonine exerts synergistic apoptotic effect with Paclitaxel (HY-B0015) in MES-SA/DX5 cells. Hydrocinchonine can be used for the study of gynecological malignant tumors (such as uterine sarcoma) with drug resistance caused by excessive expression of P-gp. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
O-Desmethyl quinidine | 99.05% | O-Desmethyl quinidine (Cupreidine) is a Cinchona alkaloid metabolite and an active product formed by O-demethylation of Quinidine (HY-B1751). It serves as a bifunctional organocatalyst and chiral resolving agent, and catalyzes enantioselective transformations through hydrogen bonding and conformational control. O-Desmethyl quinidine is used in the study of arrhythmias. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Epiquinidine | 98.99% | Epiquinidine, a quinine analogue, can be used as the ggTas2r1 agonist. Epiquinidine activates ggTas2r1 at or beyond 10 µM. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Epiquinine | Epiquinine is a stereoisomer of Quinine (HY-D0143). Epiquinine exhibits activity against chloroquine-sensitive and chloroquine-resistant Plasmodium falciparum parasites. Epiquinine can be used for the research of malaria. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Cinchonine (Standard) | ≥98% | Cinchonine (Standard) is the analytical standard of Cinchonine. This product is intended for research and analytical applications. Cinchonine is a natural compound present in Cinchona bark with antimalarial, antitumor, anti-inflammatory, anti platelet-aggregation and anti-obesity properties. Cinchonine inhibits cells proliferation and autophagy and induces apoptosis through activation of Caspase-3. Cinchonine activates endoplasmic reticulum stress-induced apoptosis in human liver cancer cells. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
