487-26-3
487-26-3
Chemical Structure
Flavanone
- CAS No.: 487-26-3
- Formula:C15H12O2
- Molecular Weight:224.26
IUPAC Name: 2-phenylchroman-4-one
InChIKey: ZONYXWQDUYMKFB-UHFFFAOYSA-N
SMILES: O=C1CC(C2=CC=CC=C2)OC3=CC=CC=C13
Biological Activity: Flavanone is a naturally occurring flavone. Flavanone has inhibitory activity for human estrogen synthetase (aromatase). Flavanone is the inhibitor for ERK/p38/NF-κB signaling pathway. Flavanone exhibits oral activity and antitumor efficacy[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Flavanone | 99.73% | Flavanone is a naturally occurring flavone. Flavanone has inhibitory activity for human estrogen synthetase (aromatase). Flavanone is the inhibitor for ERK/p38/NF-κB signaling pathway. Flavanone exhibits oral activity and antitumor efficacy. | ||||||||||||||||||||
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Flavanone (Standard) | ≥98% | Flavanone (Standard) is the analytical standard of Flavanone. This product is intended for research and analytical applications. Flavanone is a naturally occurring flavone. Flavanone has inhibitory activity for human estrogen synthetase (aromatase). lavanone is the inhibitor for ERK/p38/NF-κB signaling pathway. Flavanone exhibits oral activity and antitumor efficacy. | ||||||||||||||||||||
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2'-Hydroxyflavanone | 99.84% | 2'-Hydroxyflavanone is a flavanone that can inhibit cancer cell proliferation, induce apoptosis, and reduce inflammation. 2'-Hydroxyflavanone shows inhibitory effect on platelet aggregation caused by two inducers with IC50s 47.8 μM arachidonic acid (AA) and 147.2 μM aenosine diphosphate (ADP). | ||||||||||||||||||||
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5-Methoxyflavanone | 5-Methoxyflavanone is a 5-Methoxyflavone metabolite when fermented with Beauveria bassiana. | |||||||||||||||||||||
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(-)-Pinocembrin | 99.93% | (-)-Pinocembrin exhibits anti-mycobacterium activity against mycobacteriuum tuberculosis H37Ra with an IC50 value of 1.11 mg/mL in dormant phase and 1.21 mg/mL in active phase, respectively. (-)-Pinocembrin has potent antiproliferative activity with IC50 values of 1.88-11.00 mg/mL against THP-1, A549, Panc-1, HeLa and MCF7 cell lines. | ||||||||||||||||||||
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4'-Hydroxyflavanone | 99.75% | 4'-Hydroxyflavanone is an inhibitor of SREBP maturation and lipid synthesis. 4'-Hydroxyflavanone is a synthetic analogue of flavanone, has potential for hepatic steatosis and dyslipidemia research. | ||||||||||||||||||||
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6-Methoxyflavanone | 99.94% | 6-Methoxyflavanone (6-MeOF) is a flavonoid compound that can cross the blood-brain barrier. 6-Methoxyflavanone is a positive allosteric modulator of GABAA receptors. 6-Methoxyflavanone exhibits positive allosteric regulatory effects on human recombinant α1β2γ2L and α2β2γ2L GABAA receptors, and is relatively inactive on the α1β2 GABAA receptor. 6-Methoxyflavanone showes inhibitory behavior towards the activation of bitter receptor hTAS2R39 and hTAS2R14, demonstrating a reversible and non-overcome antagonistic effect. 6-Methoxyflavanone has the effects of anti-anxiety, analgesia and relief of neuropathic pain. | ||||||||||||||||||||
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4'-Methoxyflavanone | 99.54% | 4'-Methoxyflavanone is a flavonoid compound. 4'-Methoxyflavanone is isolated from the natural Isaria fumosorosea KCH J2. 4'-Methoxyflavanone regulates metabolic disorders, prevents cardiovascular disease and protects neurons. | ||||||||||||||||||||
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6-Hydroxyflavanone | 99.87% | 6-Hydroxyflavanone is a compound that can be isolated from the Muntingia calabura leaves. 6-Hydroxyflavanone targets cyclooxygenase-2 (COX-2), 5-lipoxygenase (5-LOX), and opioid and GABA-A receptors that has anti-inflammatory and anti-neuropathic pain potential. 6-Hydroxyflavanone can be used for the research of diabetes. | ||||||||||||||||||||
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7-Hydroxyflavanone | 99.59% | 7-Hydroxyflavanone is an aromatase (CYP19) activity inhibitor found in plants with an IC50 of 65 μM, and it also possesses 20S proteasome inhibitory activity. 7-Hydroxyflavanone significantly inhibits primary humoral immunity to SRBC in mice and weakly suppresses DTH. 7-Hydroxyflavanone 1 attenuates Doxorubicin (HY-15142A)-induced oxidative stress, IL-6 inflammation, mitochondrial dysfunction, caspase 3/7 activation, apoptosis, and necrosis, and upregulates the PGC-1α/pAMPK/Beclin-1 autophagy-related pathway. 7-Hydroxyflavanone is extensively metabolized by various fungi, undergoing multiple structural modifications. 7-Hydroxyflavanone can be used in research related to Doxorubicin-induced cardiomyopathy and immune system diseases. | ||||||||||||||||||||
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3′-Hydroxyflavanone | 3′-Hydroxyflavanone is a cyclized flavanone. 3′-Hydroxyflavanone induces apoptosis in HeLa cells. 3′-Hydroxyflavanone possesses antitumor activity. | |||||||||||||||||||||
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4-Hydroxyflavan | 4-Hydroxyflavan is a hydroxyflavan that exhibits antifungal activities against sporelings of B. cinerea (ED50 = 216 μM). 4-Hydroxyflavan can be used for antifungal research. | |||||||||||||||||||||
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References
- [1]. JT Kellis Jr, et al. Inhibition of human estrogen synthetase (aromatase) by flavones. Science. 1984 Sep. 225 (4666):1032-1034.
- [2]. Hsiao YC, et al., Flavanone and 2'-OH flavanone inhibit metastasis of lung cancer cells via down-regulation of proteinases activities and MAPK pathway. Chem Biol Interact. 2007 May 1;167(3):193-206. [Content Brief]
