487-58-1
487-58-1
Chemical Structure
Hypaphorine
- CAS No.: 487-58-1
- Formula:C14H18N2O2
- Molecular Weight:246.31
IUPAC Name: (S)-3-(1H-indol-3-yl)-2-(trimethylammonio)propanoate
InChIKey: AOHCBEAZXHZMOR-ZDUSSCGKSA-N
SMILES: C[N+](C)(C)[C@H](C([O-])=O)CC1=CNC2=CC=CC=C12
Biological Activity: Hypaphorine is an indole found in Caragana korshinskii. Hypaphorine has neurological and glucose-lowering effects. Hypaphorine prevents Lipopolysaccharides (LPS) (HY-D1056)-mediated acute lung injury (ALI) and proinflammatory response via inactivating the p38/JNK signaling pathway by upregulating DUSP1[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Hypaphorine | 99.95% | Hypaphorine is an indole found in Caragana korshinskii. Hypaphorine has neurological and glucose-lowering effects. Hypaphorine prevents Lipopolysaccharides (LPS) (HY-D1056)-mediated acute lung injury (ALI) and proinflammatory response via inactivating the p38/JNK signaling pathway by upregulating DUSP1. | ||||||||||||||||||||
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Hypaphorine (Standard) | ≥98% | Hypaphorine is an indole found in Caragana korshinskii. Hypaphorine has neurological and glucose-lowering effects. Hypaphorine prevents Lipopolysaccharides (LPS) (HY-D1056)-mediated acute lung injury (ALI) and proinflammatory response via inactivating the p38/JNK signaling pathway by upregulating DUSP1. | ||||||||||||||||||||
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L-(+)-Abrine | 99.91% | L-(+)-Abrine, a lethal albumin found in Abrus precatorius seeds, is an acute toxic alkaloid and chemical marker for abrin. | ||||||||||||||||||||
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L-Tryptophanamide hydrochloride | 99.95% | L-Tryptophanamide (H-Trp-NH2) hydrochloride is tryptophanamide hydrochloride, a primary UV standard. L-Tryptophanamide hydrochloride is a metabolite downregulated after fermentation of sea buckthorn juice by Lactobacillus plantarum or Lactiplantibacillus plantarum, and is positively correlated with bitterness and astringency in taste sensory evaluation. L-Tryptophanamide hydrochloride can be used for metabolite analysis and flavor research. | ||||||||||||||||||||
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N-Acetyl-L-tryptophan | 99.82% | N-Acetyl-L-tryptophan is an antagonist of the neurokinin-1 receptor (NK-1R), disrupting the binding of substance P (SP) to NK-1R. This action provides neuroprotective effects, improving memory deficits and motor impairments. N-Acetyl-L-tryptophan is also an inhibitor of cytochrome c (Cytochrome c), and it exerts antioxidant and anti-inflammatory effects by inhibiting the expression of IL-1β and the activation of caspase-1. N-Acetyl-L-tryptophan holds promise for research in neurodegenerative and inflammatory diseases. | ||||||||||||||||||||
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Ac-DL-Trp-OH | 98.86% | Ac-DL-Trp-OH is an endogenous metabolite. | ||||||||||||||||||||
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N-Acetyl-L-tryptophanamide | 99.51% | N-Acetyl-L-tryptophanamide (NATA) is aamino acids and their derivatives. | ||||||||||||||||||||
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α-Methyl-DL-tryptophan | 99.92% | α-Methyl-DL-tryptophan (α-Methyltryptophan), a tryptophan derivative, is a selective SLC6A14 blocker. In estrogen receptor (ER)-positive breast cancer cells, α-Methyl-DL-tryptophan inhibits mTOR and activates autophagy and apoptosis. α-Methyl-DL-tryptophan also has the effect of reducing weight. | ||||||||||||||||||||
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Glycyl-L-tryptophan | 99.93% | Glycyl-L-tryptophan (H-Gly-Trp-OH) is a polypeptide. | ||||||||||||||||||||
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D,L-Tryptophanamide hydrochloride | 99.13% | D,L-Tryptophanamide hydrochloride is a biochemical assay reagent. | ||||||||||||||||||||
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N,N-Dimethyl-L-tryptophan hydrochloride | N,N-Dimethyl-L-tryptophan hydrochloride is a tryptamine. | |||||||||||||||||||||
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N-Methyl-DL-tryptophan | N-Methyl-DL-tryptophan (N-Methyltryptophan) is a DL-tryptophan (HY-W012480) derivative with activity to stabilize tryptophan against degradation during acid hydrolysis of protein fibres. | |||||||||||||||||||||
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References
- [1]. Keller BO, et al. Hypaphorine is present in human milk in association with consumption of legumes. J Agric Food Chem. 2013 Aug 7;61(31):7654-60. [Content Brief]
- [2]. Ding YH, et al. Hypaphorine exerts anti-inflammatory effects in sepsis induced acute lung injury via modulating DUSP1/p38/JNK pathway. Kaohsiung J Med Sci. 2021 Oct;37(10):883-893. [Content Brief]
- [3]. Ditengou FA, et al. Hypaphorine from the ectomycorrhizal fungus Pisolithus tinctorius counteracts activities of indole-3-acetic acid and ethylene but not synthetic auxins in eucalypt seedlings. Mol Plant Microbe Interact. 2000 Feb;13(2):151-8. [Content Brief]
- [4]. Chand K, et al. Major alkaloidal constituent from Impatiens niamniamensis seeds as antihyperglycemic agent. Med Chem Res 20, 1505–1508 (2011).
