496807-64-8
496807-64-8
Chemical Structure
EN460
- CAS No.: 496807-64-8
- Formula:C22H12ClF3N2O4
- Molecular Weight:460.79
IUPAC Name: (Z)-2-chloro-5-(5-oxo-4-((5-phenylfuran-2-yl)methylene)-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-1-yl)benzoic acid
InChIKey: RSLFQCNAOMQAIH-WJDWOHSUSA-N
SMILES: FC(F)(F)C1=NN(C2=CC(C(O)=O)=C(Cl)C=C2)C(/C1=C\C3=CC=C(C4=CC=CC=C4)O3)=O
Biological Activity: EN460 is a selective endoplasmic reticulum oxidation 1 (ERO1) inhibitor. EN460 (IC50 of 1.9 μM) interacts selectively with the reduced, active form of ERO1α and prevents its reoxidation[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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EN460 | 99.94% | EN460 is a selective endoplasmic reticulum oxidation 1 (ERO1) inhibitor. EN460 (IC50 of 1.9 μM) interacts selectively with the reduced, active form of ERO1α and prevents its reoxidation. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.70
HY-139038TDRL-X80 -
Similarity Score 0.69
HY-145915ZINC09659342 -
Similarity Score 0.69
HY-145915A(E/Z)-ZINC09659342 -
Similarity Score 0.58
HY-13823C646 -
Similarity Score 0.58
HY-110261GS143 -
Similarity Score 0.56
HY-178287TNF-α-IN-27 -
Similarity Score 0.53
HY-153604MC4171 -
Similarity Score 0.52
HY-183829ATG5/TECAIR-IN-3 -
Similarity Score 0.52
HY-183807Autophagy-IN-13 -
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