498-95-3
498-95-3
Chemical Structure
Nipecotic acid
Synonym(s): (±)-β-Homoproline; Hexahydronicotinic acid; 3-Carboxypiperidine
- No. CAS: 498-95-3
- Formula:C6H11NO2
- Molecular Weight:129.16
IUPAC Name: piperidine-3-carboxylic acid
InChIKey: XJLSEXAGTJCILF-UHFFFAOYSA-N
SMILES: O=C(C1CNCCC1)O
Biological Activity: Nipecotic acid ((±)-β-Homoproline) is a potent inhibitor of neuronal and glial-aminobutyric acid (GABA) uptake in vitro. Nipecotic acid can also directly activate GABAA-like chloride channels, with an EC50 of approximately 300 μM[1][2].
| Referencia número | Nombre del producto | Pureza | Descripciòn | Pricing | |||||||||||||||||||
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Nipecotic acid | 97.0% | Nipecotic acid ((±)-β-Homoproline) is a potent inhibitor of neuronal and glial-aminobutyric acid (GABA) uptake in vitro. Nipecotic acid can also directly activate GABAA-like chloride channels, with an EC50 of approximately 300 μM. | ||||||||||||||||||||
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Nipecotic acid (Standard) | 99.94% | Nipecotic acid (Standard) is the analytical standard of Nipecotic acid. This product is intended for research and analytical applications. Nipecotic acid ((±)-β-Homoproline) is a potent inhibitor of neuronal and glial-aminobutyric acid (GABA) uptake in vitro. Nipecotic acid can also directly activate GABAA-like chloride channels, with an EC50 of approximately 300 μM. | ||||||||||||||||||||
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(R)-Pyrrolidine-3-carboxylic acid | 97.0% | (R)-Pyrrolidine-3-carboxylic acid is a proline derivative. | ||||||||||||||||||||
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L-Pipecolic acid | 99.89% | L-Pipecolic acid (H-HoPro-OH) is an oral active metabolite of Lysine and can accumulate in the bodily fluids of infants with autosomal inherited diseases, such as Zellweger syndrome and neonatal adrenal insufficiency. L-Pipecolic acid can promote muscle cell health and growth by enhancing protein synthesis, and plays a role in promoting gut health. L-Pipecolic acid holds promise for research in the fields of metabolic disorders, muscle growth disorders, and intestinal diseases. | ||||||||||||||||||||
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(+)-Nipecotic acid | 98.0% | (+)-Nipecotic acid ((+)-β-Homoproline) is a GABA transport inhibitor with potential antidepressant and anxiolytic activities. (+)-Nipecotic acid can increase the concentration of GABA in the synaptic cleft, thereby enhancing inhibitory neurotransmission. The research on (+)-Nipecotic acid provides a possible direction for the development of new inhibitory compounds for psychiatric diseases. | ||||||||||||||||||||
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D-Pipecolinic acid | 97.0% | D-Pipecolinic acid is a D-form cyclic amino acid with a piperidine ring structure, which is used to enhance molecular rigidity and stability. | ||||||||||||||||||||
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L-Proline | 98.0% | L-Proline is one of the twenty amino acids used in living organisms as the building blocks of proteins. | ||||||||||||||||||||
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L-Proline-13C5 | 99.93% | L-Proline-13C5 is the 13C-labeled L-Proline. L-Proline is one of the twenty amino acids used in living organisms as the building blocks of proteins. | ||||||||||||||||||||
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Azetidine-3-carboxylic acid | 98.0% | Azetidine-3-carboxylic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azetidine-3-carboxylic acid is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[2 | ||||||||||||||||||||
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Pipecolic acid | 99.92% | Pipecolic acid is an orally bioavailable, blood-brain barrier-permeable metabolite of lysine with antioxidant, inhibitor, and inducer activity. Pipecolic acid modulates the YAP-GPX4 signaling pathway, reduces retinal vascular tube formation, and mitigates ferroptosis. Pipecolic acid potentiates voltage-sensitive Ca2+ channel currents and induces neuronal apoptosis. Pipecolic acid can be used for the research of diabetic retinopathy. | ||||||||||||||||||||
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Isonipecotic acid | 99.93% | Isonipecotic acid is a GABAA receptor partial agonist. | ||||||||||||||||||||
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Cyclohexanecarboxylic acid (Standard) | ≥98% | Cyclohexanecarboxylic acid (Standard) is the analytical standard of Cyclohexanecarboxylic acid. This product is intended for research and analytical applications. Cyclohexanecarboxylic acid is a Valproate structural analogue with anticonvulsant action. | ||||||||||||||||||||
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References
- [1]. Barrett-Jolley R, et, al. Nipecotic acid directly activates GABA(A)-like ion channels. Br J Pharmacol. 2001 Jul;133(5):673-8. [Content Brief]
- [2]. Dhanawat M, et, al. Design, Synthesis and Enhanced BBB Penetration Studies of L-serine-Tethered Nipecotic Acid-Prodrug. Drug Res (Stuttg). 2021 Feb;71(2):94-103. [Content Brief]
